Effect of megestrol acetate on the human pituitary-adrenal axis
A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis...
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| Published in | Mayo Clinic proceedings Vol. 67; no. 12; p. 1160 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.12.1992
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| Subjects | |
| Online Access | Get more information |
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| Abstract | A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis in patients receiving megestrol acetate (160 or 800 mg/day). The data from these evaluations demonstrate that megestrol acetate reversibly decreases serum cortisol concentrations in humans and that this effect seems to originate from a suppression of the pituitary-adrenal axis. Additional studies should be conducted to determine the implications of the low levels of serum cortisol. |
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| AbstractList | A few previous reports have suggested that megestrol acetate, a synthetic progestational agent frequently used as an antineoplastic drug, suppresses serum cortisol concentrations in humans. To explore this concept further, we prospectively performed several measurements of the pituitary-adrenal axis in patients receiving megestrol acetate (160 or 800 mg/day). The data from these evaluations demonstrate that megestrol acetate reversibly decreases serum cortisol concentrations in humans and that this effect seems to originate from a suppression of the pituitary-adrenal axis. Additional studies should be conducted to determine the implications of the low levels of serum cortisol. |
| Author | Loprinzi, C L Jiang, N S Schaid, D J Jensen, M D |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1469926$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Humans Hydrocortisone - blood Megestrol - analogs & derivatives Megestrol - pharmacology Megestrol Acetate Pituitary-Adrenal System - drug effects Prospective Studies |
| Title | Effect of megestrol acetate on the human pituitary-adrenal axis |
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