A specific haplotype in potential miRNAs binding sites of secreted frizzled-related protein 1 (SFRP1) is associated with BMD variation in osteoporosis

• Published in: Gene Vol. 677; pp. 132 - 141
• Main Authors: Amjadi-Moheb, Fatemeh, Hosseini, Seyed Reza, Kosari-Monfared, Mohadeseh, Ghadami, Elham, Nooreddini, Hajighorban, Akhavan-Niaki, Haleh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.11.2018
• Subjects: 3' untranslated regions; 3' Untranslated Regions - genetics; Aged; algorithms; Alleles; binding sites; Binding Sites - genetics; bioinformatics; bone density; Bone Density - genetics; elderly; Female; femur; Femur Neck - metabolism; Genotype; genotyping; Haplotype; haplotypes; Haplotypes - genetics; Humans; Intercellular Signaling Peptides and Proteins - genetics; introns; lumbar spine; Lumbar Vertebrae - metabolism; Male; males; Membrane Proteins - genetics; microRNA; MicroRNAs - genetics; Middle Aged; mineral content; Osteoporosis; Osteoporosis - genetics; patients; people; polymerase chain reaction; Polymorphism, Restriction Fragment Length - genetics; Polymorphism, Single Nucleotide - genetics; regression analysis; restriction fragment length polymorphism; SFRP1; signal transduction; Single nucleotide polymorphism; Wnt Proteins - genetics; Wnt signaling pathway; WNT5b; Wnt signaling pathway; WNT5b; MFE; Osteoporosis; SFRP1; SNP; BMD; BMC; Single nucleotide polymorphism; Haplotype; PCR; RFLP; BMI

Osteoporosis is an important multifactorial disease which is largely influenced by Wnt signaling pathway. Considering regulatory single nucleotide polymorphisms in Wnt signaling pathway may pave the road of understanding the genetic basis of predisposition to osteoporosis. The aim of this study was...