Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 7; p. e2318586121
• Main Authors: DeMars, Matthew D., O’Connor, Sarah E.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.02.2024
• Subjects: Alkaloids; Aspidosperma - metabolism; Biological Sciences; Biosynthesis; Carboxylesterase; Carboxylesterase - metabolism; Catharanthus - metabolism; Chimeras; Cycloaddition; Enzymes; Evolution; Indole Alkaloids - metabolism; Metabolic pathways; Metabolites; Natural products; Phylogeny; Plants - metabolism; Protein families; Secologanin Tryptamine Alkaloids - chemistry; Secologanin Tryptamine Alkaloids - metabolism; Tabernaemontana - metabolism; natural product biosynthesis; ancestral sequence reconstruction; cycloaddition; monoterpene indole alkaloids

Monoterpene indole alkaloids (MIAs) are a large and diverse class of plant natural products, and their biosynthetic construction has been a subject of intensive study for many years. The enzymatic basis for the production of aspidosperma and iboga alkaloids, which are produced exclusively by members...