Expression of the two insulin receptor isoforms is not altered in the skeletal muscle and liver of diabetic rats

• Published in: Metabolism, clinical and experimental Vol. 47; no. 2; pp. 129 - 132
• Main Authors: Sbraccia, P., Giaccari, A., D'Adamo, M., Caiola, S., Morviducci, L., Zorretta, D., Maroccia, E., Buongiorno, A., Tamburrano, G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1998; Elsevier
• Subjects: Animals; Biological and medical sciences; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - metabolism; Endocrinopathies; Humans; Hypothalamus. Hypophysis. Epiphysis (diseases); Liver - chemistry; Male; Medical sciences; Muscle, Skeletal - chemistry; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Rats; Rats, Sprague-Dawley; Receptor, Insulin - analysis; Receptor, Insulin - genetics; RNA, Messenger - analysis; Endocrinopathy; Pancreatic hormone; Molecular form; Rat; Liver; Rodentia; Gene expression; Striated muscle; Non insulin dependent diabetes; Insulin; Polymerase chain reaction; Protein hormone; Vertebrata; Mammalia; Animal; Molecular biology; Hormonal receptor

Alternative splicing of the 36—base pair exon 11 of the human insulin receptor (IR) gene and of the corresponding domain of the rat IR gene results in the synthesis of two IR isoforms with distinct functional characteristics. Altered expression of these IR isoforms has been previously demonstrated i...