3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion
The aim of the present study was to describe the synthesis of a t rimethyl c yclohexenonic long chain f atty a lcohol ( t-CFA), and analyze its biological activity. Specifically, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one, the t-CFA containing 15 carbon atoms on the side chain ( t-C...
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Published in | Bioorganic & medicinal chemistry letters Vol. 10; no. 22; pp. 2537 - 2539 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
20.11.2000
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of the present study was to describe the synthesis of a
t
rimethyl
c
yclohexenonic long chain
f
atty
a
lcohol (
t-CFA), and analyze its biological activity. Specifically, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one, the
t-CFA containing 15 carbon atoms on the side chain (
t-CFA
n=15) stimulated arginine vasopressin secretion in nerve terminals of the neurohypophysis. This effect was inhibited by extracellular calcium depletion, which suggets that
t-CFA
n=15 stimulates neuropeptide secretion through a calcium-dependent exocytosis mechanism. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(00)00508-4 |