The minor allele of ANGPTL8 rs2278426 has a protective effect against CAD in T2DM patients

• Published in: Gene Vol. 914; p. 148418
• Main Authors: Bilgin, Aslihan Gizem, Ekici, Berkay, Ozuynuk-Ertugrul, Aybike Sena, Erkan, Aycan Fahri, Coban, Neslihan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2024
• Subjects: Aged; Alleles; angiography; Angiopoietin-Like Protein 8; Angiopoietin-like Proteins - genetics; ANGPTL8; CAD; Coronary Angiography; coronary artery disease; Coronary Artery Disease - genetics; death; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genotyping; Humans; lipids; Male; males; Middle Aged; noninsulin-dependent diabetes mellitus; obesity; pathogenesis; Peptide Hormones - genetics; Polymorphism; Polymorphism, Single Nucleotide; protective effect; quantitative polymerase chain reaction; regression analysis; risk; Risk Factors; Rs2278426; T2DM; Turkey; Turkey; T2DM; HDL; TG; LDL; ANGPTL8; CAD; LPL; Rs2278426; PCR; Polymorphism; BMI

[Display omitted] •Minor allele frequency of rs2278426 was measured as 10.18% in Turkish individuals.•T allele carriage has a protective effect against T2DM in CAD group.•T allele carrier T2DM patients had lower stenosis percentages in the CAD group.•ANGPTL8 could not directly bind to ANGPTL3/4 acco...