Lupus anticoagulant and pregnancy

• Published in: American journal of obstetrics and gynecology Vol. 153; no. 3; p. 322
• Main Authors: Lubbe, W F, Liggins, G C
• Format: Journal Article
• Language: English
• Published: United States 01.10.1985
• Subjects: Aspirin - therapeutic use; Autoantibodies - analysis; Autoantibodies - immunology; Blood Coagulation Factors - analysis; Blood Coagulation Factors - antagonists & inhibitors; Blood Coagulation Factors - immunology; Female; Fetal Death - etiology; Fetal Diseases - etiology; Fetal Growth Retardation - etiology; Humans; Immunosuppression; Infant, Newborn; Lupus Coagulation Inhibitor; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - therapy; Partial Thromboplastin Time; Prednisone - adverse effects; Prednisone - therapeutic use; Pregnancy; Pregnancy Complications - etiology; Pregnancy Complications - immunology; Pregnancy Complications - therapy; Pregnancy Complications, Hematologic - etiology; Pregnancy Complications, Hematologic - therapy; Thrombosis - etiology; Thrombosis - therapy

A subset of women with a high rate of fetal wastage is identifiable among those with serologic but not necessarily clinical evidence of connective tissue disease. The presence of lupus anticoagulant in the plasma of a pregnant woman serves as a marker for a high rate of fetal wastage and risk of thr...