RNAi inhibition of Pax3/7 expression leads to markedly decreased expression of muscle determination genes

• Published in: Molecular and cellular biochemistry Vol. 302; no. 1-2; pp. 257 - 262
• Main Authors: Bhagavati, Satyakam, Song, Xiaosong, Siddiqui, M A Q
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.08.2007
• Subjects: Animals; Cell Differentiation - genetics; Cells; Embryonic Stem Cells - metabolism; Gene Expression Regulation, Developmental; Mice; Muscular system; Myogenic Regulatory Factors - genetics; Paired Box Transcription Factors - genetics; PAX3 Transcription Factor; PAX7 Transcription Factor - genetics; RNA Interference

Skeletal muscle regeneration by cell transplantation for the treatment of muscle diseases requires the identification and isolation of well-defined, early skeletal muscle progenitor cells. It is known that myogenesis is governed by the sequential and compound activation of the muscle determination g...