Selection of a Peptide Ligand to the p75 Neurotrophin Receptor Death Domain and Determination of Its Binding Sites by NMR

• Published in: Biochemical and biophysical research communications Vol. 255; no. 1; pp. 104 - 109
• Main Authors: Ilag, Leopold L., Rottenberger, Christine, Liepinsh, Edvards, Wellnhofer, Günter, Rudert, Fritz, Otting, Gottfried, Ilag, Leodevico L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.02.1999
• Subjects: Amino Acid Sequence; Binding Sites; Ligands; Magnetic Resonance Spectroscopy; Medicin och hälsovetenskap; Molecular Sequence Data; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Protein Binding; Protein Conformation; Receptor, Nerve Growth Factor - chemistry; Receptor, Nerve Growth Factor - metabolism; Signal Transduction

The p75 neurotrophin receptor (p75NTR) contains a conserved death domain module similar to that of the cytotoxic receptors Fas and TNFR-1. Here, we describe the selection of peptide ligands from a combinatorial library using a variation of the selectively-infective phage (SIP) method directed to the...