Loss of heterozygosity in clinical stage IB cervical carcinoma: Relationship with clinical and histopathologic features

• Published in: Human pathology Vol. 29; no. 4; pp. 364 - 370
• Main Authors: Huettner, Phyllis C, Gerhard, Daniela S, Li, Lina, Gersell, Deborah J, Dunnigan, Keith, Kamarasova, Tatiana, Rader, Janet S
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1998; Elsevier
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; allelotyping; Biological and medical sciences; Carcinoma - genetics; Carcinoma - pathology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; cervical cancer; Chromosome Deletion; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 6; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Heterozygote; Humans; loss of heterozygosity; Medical sciences; Prognosis; prognostic factors; Tumors; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - pathology; FAL; UV; LOH; allelotyping; LVS; ESG; CIN; prognostic factors; loss of heterozygosity; cervical cancer; PCR; HPV; Human; Carcinoma; Prognosis; Typing; Malignant tumor; Uterine cervix; Female genital diseases; Polymerase chain reaction; Pathology; Allele; Clinical stage; Loss of heterozygosity; Female; Molecular biology; Uterine cervix diseases

Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasms. The relationship between LOH and established histopathological prognostic factors in cervical carcinoma has not been examined. We studied LOH in 58 FIGO stage IB cervical cancers tre...