Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor
Here, we explored flotillin-1-mediated regulation of insulin-like growth factor-1 (IGF-1) signaling. Flotillin-1-deficient cells exhibited a reduction in the activation of IGF-1 receptor (IGF-1R), ERK1/2 and Akt pathways, and the transcriptional activation of Elk-1 and the proliferation in response...
Saved in:
Published in | Journal of cell science Vol. 128; no. 11; pp. 2179 - 2190 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.06.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Be the first to leave a comment!