Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor

Here, we explored flotillin-1-mediated regulation of insulin-like growth factor-1 (IGF-1) signaling. Flotillin-1-deficient cells exhibited a reduction in the activation of IGF-1 receptor (IGF-1R), ERK1/2 and Akt pathways, and the transcriptional activation of Elk-1 and the proliferation in response...

Full description

Saved in:
Bibliographic Details
Published inJournal of cell science Vol. 128; no. 11; pp. 2179 - 2190
Main Authors Jang, Donghwan, Kwon, Hayeong, Jeong, Kyuho, Lee, Jaewoong, Pak, Yunbae
Format Journal Article
LanguageEnglish
Published England 01.06.2015
Subjects
Online AccessGet full text

Cover

Loading…