Transplantation of feces from mice with Alzheimer's disease promoted lung cancer growth

• Published in: Biochemical and biophysical research communications Vol. 600; pp. 67 - 74
• Main Authors: Bi, Wangyu, Cai, Shanglin, Hang, Zhongci, Lei, Tong, Wang, Donghui, Wang, Li, Du, Hongwu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.04.2022
• Subjects: Alzheimer disease; Alzheimer Disease - pathology; Alzheimer's disease; Animals; Bacteroides; bcl-2-Associated X Protein; Bifidobacterium; brain; Coprobacillus; digestive system; epidemiology; Fecal microbiota transplantation; Feces; genes; Gut microbiota; Halomonas; intestinal microorganisms; Lewis lung cancer; Lung Neoplasms; Mice; morbidity; mortality; Mucispirillum; Prevotella; prognosis; Proto-Oncogene Proteins c-akt; RNA, Ribosomal, 16S; Gut microbiota; Lewis lung cancer; Alzheimer's disease; Fecal microbiota transplantation
• ISSN: 0006-291X; 1090-2104; 1090-2104
• DOI: 10.1016/j.bbrc.2022.01.078

Alzheimer's disease (AD) is a progressive neurologic disorder that causes the brain to shrink and brain cells to die. Lung cancer is characterized by high morbidity and mortality, late diagnosis and poor prognosis. And there is no specific mechanism to explain the epidemiological correlation between AD and lung cancer. Lewis lung cancer cells (LLC) were injected into the left forelimb armpit of APP/PS1 mice to establish a tumor-bearing model. After remodeling the gut microbiota by fecal microbiota transplantation (FMT), the tumor were collected and analyzed for tumor size, Western blotting, and 16S rRNA gene sequencing. Compared with the control group, the AD FMT group showed larger tumors, while C57 FMT group showed smaller tumors. The former group showed the inhibition of AKT/Bax/Bcl-2 pathway, while the latter showed promotion of Caspase-1/IL-1β and AKT/Bax/Bcl-2 pathway, which induced changes in tumor size. And Prevotella, Prevotella, Mucispirillum and Halomonas in the gut lumen of LLC tumor-bearing mice are increased, and Bacteroides, Coprobacillus, Bifidobacterium, Faecalibacterium and Aggregatiacter are decreased significantly. AD and lung cancer showed a positive correlation in APP expression, which proposed a different view from epidemiology on the correlation between AD and lung cancer. •AD and lung cancer are similar in pathogenesis, which is related to APP.•AD and C57 FMT change gut microbiota in the opposite direction.•AD FMT increase tumors by inhibiting apoptosis pathways.•C57 FMT inhibits tumors by promoting apoptotic pathways.