Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population

• Published in: Gene Vol. 626; pp. 319 - 325
• Main Authors: Zeng, Ting-Ting, Tang, Di-Jiao, Ye, Yuan-Xin, Su, Jun, Jiang, Hong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.08.2017
• Subjects: Adult; Aged; Aged, 80 and over; alleles; blood lipids; Case-Control Studies; Cerebral infarction; Cerebral Infarction - genetics; China; Chinese people; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; coronary disease; Coronary Disease - genetics; Coronary heart disease; Female; gender; haplotypes; high density lipoprotein; Humans; infarction; Lipoproteins, HDL - blood; Lipoproteins, HDL - genetics; Male; melting; Middle Aged; patients; Polymorphism, Single Nucleotide; protein synthesis; receptors; risk; SCARB1 gene; Scavenger Receptors, Class B - genetics; Serum lipids; single nucleotide polymorphism; SNPs; GWASs; Cerebral infarction; SR-BI; HRM; OR; miRNAs; LDL-c; CI; VTE; CIs; cholesterol-c; Coronary heart disease; Lp-PLA2; SCARB1 gene; HDL-c; Serum lipids; TG; MAF; HWE; SNPs; Tm; CHD; PCR; CCIMT

The SCARB1 gene encodes human scavenger receptor class B type I (SR-BI), the primary receptor for high-density lipoprotein (HDL)- cholesteryl ester uptake, and polymorphisms in this gene may influence SR-BI protein expression and serum lipid levels, modulating susceptibility to coronary heart diseas...