Immunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss)
In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in ra...
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| Published in | Journal of comparative pathology Vol. 150; no. 2-3; pp. 258 - 265 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2014
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| Subjects | |
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| Abstract | In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human α-smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms. |
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| AbstractList | In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human α-smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms. Summary In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human alpha -smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms. |
| Author | Alves, V.A.F. Arana, S. Nonogaki, S. Hernandez-Blazquez, F.J. Zaidan-Dagli, M.-L. Tabata, Y.A. Sabino, M. |
| Author_xml | – sequence: 1 givenname: S. surname: Arana fullname: Arana, S. email: aranas@unicamp.br organization: Department of Histology and Embryology, Institute of Biology, University of Campinas (UNICAMP), CP: 6109, CEP: 13083-970 Campinas, São Paulo, Brazil – sequence: 2 givenname: V.A.F. surname: Alves fullname: Alves, V.A.F. organization: Department of Pathology, School of Medicine, São Paulo University, São Paulo – sequence: 3 givenname: M. surname: Sabino fullname: Sabino, M. organization: Adolfo Lutz Institute, São Paulo, Brazil – sequence: 4 givenname: Y.A. surname: Tabata fullname: Tabata, Y.A. organization: Estação Experimental de Salmonicultura Dr. Ascânio de Faria, APTA, Secretaria de Agricultura e Abastecimento de São Paulo, São Paulo, Brazil – sequence: 5 givenname: S. surname: Nonogaki fullname: Nonogaki, S. organization: Adolfo Lutz Institute, São Paulo, Brazil – sequence: 6 givenname: M.-L. surname: Zaidan-Dagli fullname: Zaidan-Dagli, M.-L. organization: Department of Pathology, School of Veterinary Medicine and Animal Sciences, São Paulo University, São Paulo, Brazil – sequence: 7 givenname: F.J. surname: Hernandez-Blazquez fullname: Hernandez-Blazquez, F.J. organization: Department of Surgery, School of Veterinary Medicine and Animal Science, São Paulo University, São Paulo, Brazil |
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| CitedBy_id | crossref_primary_10_3390_toxins10120543 crossref_primary_10_1002_ijc_30782 crossref_primary_10_3390_foods12051006 crossref_primary_10_3390_su15065418 crossref_primary_10_1016_j_envpol_2017_10_067 crossref_primary_10_1016_j_prp_2014_08_007 crossref_primary_10_1007_s11626_022_00734_2 crossref_primary_10_1136_bmjgast_2020_000380 crossref_primary_10_3390_toxins7114595 crossref_primary_10_1016_j_aquaculture_2020_735055 crossref_primary_10_1016_j_cbpc_2019_03_007 |
| Cites_doi | 10.1016/j.bpg.2011.02.004 10.1016/j.jhep.2009.01.028 10.4161/cam.20377 10.1177/019262339101900306 10.1016/j.prp.2010.12.002 10.1152/physrev.00013.2007 10.1002/hep.1840060111 10.1177/019262339502300402 10.1177/0300985811409443 10.1172/JCI24282 10.1093/toxsci/kfi309 10.1002/hep.1840040425 10.4103/1319-3767.96445 10.1002/hep.510260612 10.1590/S0100-736X2011000900005 10.1136/gut.46.4.443 10.1080/01926230590890187 10.1007/s10735-007-9078-5 10.1111/j.1440-1746.2011.07002.x 10.1093/carcin/20.6.933 10.1177/019262330002800215 10.1097/MOG.0b013e328351d003 10.1177/0192623312464308 10.1016/j.tox.2007.09.007 10.1093/carcin/16.5.1059 10.1002/bdrc.20205 10.1074/jbc.M006101200 10.1016/j.mam.2007.09.002 10.1679/aohc.66.437 10.1016/S0016-5085(97)70143-4 |
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| Keywords | liver fibrosis hepatocarcinogenesis myofibroblast fish |
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| References | Couch, Courtney (bib11) 1987; 79 Okihiro, Hinton (bib25) 1999; 20 Bioulac-Sage, Blanc, Lepreux, Balabaud, Rosenbaum (bib7) 2000; 24 Senda, Nomura (bib32) 2003; 66 Arana, Dagli, Sabino, Tabata, Rigolino (bib2) 2011; 31 Wolf, Wolfe (bib39) 2005; 33 Neaud, Hisaka, Monvoisin, Bedin, Balabaud (bib23) 2000; 275 Bunton (bib8) 1995; 16 Arana, Tabata, Sabino, Rigolino, Hernandez-Blazquez (bib3) 2002; 4 Tilton, Gerwick, Hendricks, Rosato, Corley-Smith (bib35) 2005; 88 Hendricks, Shelton, Loveland, Pereira, Bailey (bib15) 1995; 23 Bataller, Brenner (bib5) 2005; 115 Williams (bib37) 2012; 155 Neaud, Faouzi, Guirouilh, Le Bail, Balabaud (bib22) 1997; 26 Yamamoto, Sargent, Fisher, Youson (bib41) 1986; 6 Van Wettere, Law, Hinton, Kullman (bib36) 2013; 41 Li, Kong, Wang, Wang, Yu (bib19) 2009; 50 Otranto, Sarrazy, Bonté, Hinz, Gabbiani (bib27) 2012; 6 Starkel, Leclercq (bib34) 2011; 25 Williams, Bailey, Reddy, Hendricks, Oganesian (bib38) 2003; 31 Rahimi, Rockey (bib29) 2012; 28 Soares, Rodriguez-Amaya (bib33) 1989; 72 Zhao, Burt (bib43) 2007; 38 Schmitt-Gräff, Krüger, Bochard, Gabbiani, Denk (bib31) 1991; 138 Hendricks, Meyers, Shelton (bib14) 1984; 65 Benyon, Iredale (bib6) 2000; 46 Makovicky, Dudova, Tumova, Rajmon, Vodkova (bib21) 2011; 207 Yokoi, Namihisa, Kuroda, Komatsu, Miyazaki (bib42) 1984; 4 Yamamoto, Itoh, Adachi, Sakamoto, Adachi (bib40) 1997; 112 Rekha, Amali, Her, Yeh, Gong (bib30) 2008; 243 Hobbie, DeAngelo, George, Law (bib17) 2012; 49 Couch (bib10) 1991; 19 Friedman (bib12) 2008; 88 Lu, Hsia, Tu, Hsiao, Yang (bib20) 2011; 3 Ochiai, Handharyani, Umemura (bib24) 2003; 32 Iwaisako, Brenner, Kisseleva (bib18) 2012; 27 Hinton, Couch (bib16) 1998 Okihiro, Hinton (bib26) 2000; 28 Ahmad, Ahmad (bib1) 2012; 18 Choi, Omenetti, Witek, Moylan, Syn (bib9) 2009; 297 Bailey, Williams, Hendricks (bib4) 1996; 104 Parola, Marra, Pinzani (bib28) 2008; 29 Ahmad (10.1016/j.jcpa.2013.07.003_bib1) 2012; 18 Van Wettere (10.1016/j.jcpa.2013.07.003_bib36) 2013; 41 Benyon (10.1016/j.jcpa.2013.07.003_bib6) 2000; 46 Bunton (10.1016/j.jcpa.2013.07.003_bib8) 1995; 16 Li (10.1016/j.jcpa.2013.07.003_bib19) 2009; 50 Yamamoto (10.1016/j.jcpa.2013.07.003_bib40) 1997; 112 Tilton (10.1016/j.jcpa.2013.07.003_bib35) 2005; 88 Bailey (10.1016/j.jcpa.2013.07.003_bib4) 1996; 104 Yamamoto (10.1016/j.jcpa.2013.07.003_bib41) 1986; 6 Neaud (10.1016/j.jcpa.2013.07.003_bib23) 2000; 275 Okihiro (10.1016/j.jcpa.2013.07.003_bib25) 1999; 20 Senda (10.1016/j.jcpa.2013.07.003_bib32) 2003; 66 Wolf (10.1016/j.jcpa.2013.07.003_bib39) 2005; 33 Parola (10.1016/j.jcpa.2013.07.003_bib28) 2008; 29 Choi (10.1016/j.jcpa.2013.07.003_bib9) 2009; 297 Hobbie (10.1016/j.jcpa.2013.07.003_bib17) 2012; 49 Rekha (10.1016/j.jcpa.2013.07.003_bib30) 2008; 243 Yokoi (10.1016/j.jcpa.2013.07.003_bib42) 1984; 4 Bioulac-Sage (10.1016/j.jcpa.2013.07.003_bib7) 2000; 24 Bataller (10.1016/j.jcpa.2013.07.003_bib5) 2005; 115 Neaud (10.1016/j.jcpa.2013.07.003_bib22) 1997; 26 Hendricks (10.1016/j.jcpa.2013.07.003_bib15) 1995; 23 Iwaisako (10.1016/j.jcpa.2013.07.003_bib18) 2012; 27 Lu (10.1016/j.jcpa.2013.07.003_bib20) 2011; 3 Otranto (10.1016/j.jcpa.2013.07.003_bib27) 2012; 6 Starkel (10.1016/j.jcpa.2013.07.003_bib34) 2011; 25 Hendricks (10.1016/j.jcpa.2013.07.003_bib14) 1984; 65 Hinton (10.1016/j.jcpa.2013.07.003_bib16) 1998 Okihiro (10.1016/j.jcpa.2013.07.003_bib26) 2000; 28 Rahimi (10.1016/j.jcpa.2013.07.003_bib29) 2012; 28 Schmitt-Gräff (10.1016/j.jcpa.2013.07.003_bib31) 1991; 138 Arana (10.1016/j.jcpa.2013.07.003_bib3) 2002; 4 Couch (10.1016/j.jcpa.2013.07.003_bib11) 1987; 79 Makovicky (10.1016/j.jcpa.2013.07.003_bib21) 2011; 207 Couch (10.1016/j.jcpa.2013.07.003_bib10) 1991; 19 Ochiai (10.1016/j.jcpa.2013.07.003_bib24) 2003; 32 Soares (10.1016/j.jcpa.2013.07.003_bib33) 1989; 72 Williams (10.1016/j.jcpa.2013.07.003_bib38) 2003; 31 Friedman (10.1016/j.jcpa.2013.07.003_bib12) 2008; 88 Williams (10.1016/j.jcpa.2013.07.003_bib37) 2012; 155 Arana (10.1016/j.jcpa.2013.07.003_bib2) 2011; 31 Zhao (10.1016/j.jcpa.2013.07.003_bib43) 2007; 38 |
| References_xml | – volume: 79 start-page: 297 year: 1987 end-page: 321 ident: bib11 article-title: N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow ( publication-title: Journal of the National Cancer Institute contributor: fullname: Courtney – volume: 3 start-page: 157 year: 2011 end-page: 172 ident: bib20 article-title: Liver development and cancer formation in zebrafish publication-title: Birth Defects Research (Part C) contributor: fullname: Yang – volume: 275 start-page: 35565 year: 2000 end-page: 35569 ident: bib23 article-title: Paradoxical pro-invasive effect of the serine proteinase inhibitor tissue factor pathway inhibitor-2 on human hepatocellular carcinoma cells publication-title: Journal of Biological Chemistry contributor: fullname: Balabaud – volume: 28 start-page: 223 year: 2012 end-page: 229 ident: bib29 article-title: Complications of cirrhosis publication-title: Current Opinion in Gastroenterology contributor: fullname: Rockey – volume: 18 start-page: 155 year: 2012 end-page: 167 ident: bib1 article-title: Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches publication-title: Saudi Journal of Gastroenterology contributor: fullname: Ahmad – volume: 26 start-page: 1458 year: 1997 end-page: 1466 ident: bib22 article-title: Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor publication-title: Hepatology contributor: fullname: Balabaud – volume: 41 start-page: 744 year: 2013 end-page: 760 ident: bib36 article-title: Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury publication-title: Toxicologic Pathology contributor: fullname: Kullman – volume: 4 start-page: 709 year: 1984 end-page: 714 ident: bib42 article-title: Immunocytochemical detection of desmin in fat-storing cells (Ito cells) publication-title: Hepatology contributor: fullname: Miyazaki – volume: 24 start-page: 877 year: 2000 end-page: 882 ident: bib7 article-title: Cirrhosis: forever? publication-title: Gastroenterologie Clinique et Biologique contributor: fullname: Rosenbaum – volume: 243 start-page: 11 year: 2008 end-page: 22 ident: bib30 article-title: Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish, publication-title: Toxicology contributor: fullname: Gong – volume: 112 start-page: 1290 year: 1997 end-page: 1296 ident: bib40 article-title: Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma publication-title: Gastroenterology contributor: fullname: Adachi – volume: 6 start-page: 54 year: 1986 end-page: 59 ident: bib41 article-title: Periductal fibrosis and lipocytes (fat-storing cells or Ito cells) during biliary atresia in the lamprey publication-title: Hepatology contributor: fullname: Youson – volume: 104 start-page: 5 year: 1996 end-page: 19 ident: bib4 article-title: Fish models for environmental carcinogenesis: the rainbow trout publication-title: Environmental Health Perspective contributor: fullname: Hendricks – volume: 25 start-page: 319 year: 2011 end-page: 333 ident: bib34 article-title: Animal models for the study of hepatic fibrosis publication-title: Best Practice and Research in Clinical Gastroenterology contributor: fullname: Leclercq – volume: 297 start-page: G1093 year: 2009 end-page: G1106 ident: bib9 article-title: Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis publication-title: American Journal of Physiology: Gastrointestinal and Liver Physiology contributor: fullname: Syn – volume: 32 start-page: 425 year: 2003 end-page: 458 ident: bib24 article-title: Idiopathic hepatic fibrosis with cholestasis in broiler chickens: immunohistochemistry of hepatic stellate cells publication-title: Avian Pathology contributor: fullname: Umemura – volume: 155 start-page: 121 year: 2012 end-page: 127 ident: bib37 article-title: The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention publication-title: Comparative Biochemistry and Physiology Part C contributor: fullname: Williams – volume: 23 start-page: 447 year: 1995 end-page: 457 ident: bib15 article-title: Carcinogenicity of dietary dimethylnitrosomorpholine, publication-title: Toxicologic Pathology contributor: fullname: Bailey – volume: 66 start-page: 437 year: 2003 end-page: 444 ident: bib32 article-title: The expression of cytokeratin in hepatic stellate cells of the cod publication-title: Archives of Histology and Cytology contributor: fullname: Nomura – volume: 38 start-page: 53 year: 2007 end-page: 64 ident: bib43 article-title: The diffuse stellate cell system publication-title: Journal of Molecular Histology contributor: fullname: Burt – volume: 19 start-page: 237 year: 1991 end-page: 250 ident: bib10 article-title: Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model publication-title: Toxicologic Pathology contributor: fullname: Couch – volume: 31 start-page: 58 year: 2003 end-page: 61 ident: bib38 article-title: The rainbow trout ( publication-title: Toxicologic Pathology contributor: fullname: Oganesian – volume: 88 start-page: 125 year: 2008 end-page: 172 ident: bib12 article-title: Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver publication-title: Physiology Reviews contributor: fullname: Friedman – start-page: 141 year: 1998 end-page: 163 ident: bib16 article-title: Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses publication-title: Fish Ecotoxicology contributor: fullname: Couch – volume: 138 start-page: 1233 year: 1991 end-page: 1242 ident: bib31 article-title: Modulation of alpha-smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers publication-title: American Journal of Pathology contributor: fullname: Denk – volume: 115 start-page: 209 year: 2005 end-page: 218 ident: bib5 article-title: Liver fibrosis publication-title: Journal of Clinical Investigation contributor: fullname: Brenner – volume: 50 start-page: 1174 year: 2009 end-page: 1183 ident: bib19 article-title: Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis publication-title: Journal of Hepatology contributor: fullname: Yu – volume: 65 start-page: 321 year: 1984 end-page: 336 ident: bib14 article-title: Histological progression of hepatic neoplasia in rainbow trout ( publication-title: National Cancer Institute Monographs contributor: fullname: Shelton – volume: 29 start-page: 58 year: 2008 end-page: 66 ident: bib28 article-title: Myofibroblast-like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario publication-title: Molecular Aspects of Medicine contributor: fullname: Pinzani – volume: 27 start-page: 65 year: 2012 end-page: 68 ident: bib18 article-title: What’s new in liver fibrosis? The origin of myofibroblasts in liver fibrosis publication-title: Journal of Gastroenterology and Hepatology contributor: fullname: Kisseleva – volume: 46 start-page: 443 year: 2000 end-page: 446 ident: bib6 article-title: Is liver fibrosis reversible? publication-title: Gut contributor: fullname: Iredale – volume: 16 start-page: 1059 year: 1995 end-page: 1063 ident: bib8 article-title: Expression of actin and desmin in experimentally induced hepatic lesions and neoplasm from medaka ( publication-title: Carcinogenesis contributor: fullname: Bunton – volume: 207 start-page: 151 year: 2011 end-page: 155 ident: bib21 article-title: Experimental study of non-alcoholic fatty liver disease (NAFLD) on a model of starving chickens: is generalization of steatosis accompanied by fibrosis of the liver tissue? publication-title: Pathology Research and Practice contributor: fullname: Vodkova – volume: 28 start-page: 342 year: 2000 end-page: 356 ident: bib26 article-title: Partial hepatectomy and bile duct ligation in rainbow trout, ( publication-title: Toxicologic Pathology contributor: fullname: Hinton – volume: 6 start-page: 203 year: 2012 end-page: 219 ident: bib27 article-title: The role of the myofibroblast in tumor stroma remodeling publication-title: Cell Adhesion and Migration contributor: fullname: Gabbiani – volume: 72 start-page: 22 year: 1989 end-page: 26 ident: bib33 article-title: Survey of aflatoxins, ochratoxin A, zearalenone and sterigmatocystin in some Brazilian foods by using multi-toxin thin-layer chromatographic method publication-title: Journal of the Association of Official Analytical Chemists contributor: fullname: Rodriguez-Amaya – volume: 31 start-page: 751 year: 2011 end-page: 755 ident: bib2 article-title: Evaluation of the efficacy of hydrated sodium aluminosilicate in the prevention of aflatoxin-induced hepatic cancer in rainbow trout publication-title: Pesquisa Veterinária Brasileira contributor: fullname: Rigolino – volume: 49 start-page: 372 year: 2012 end-page: 385 ident: bib17 article-title: Neoplastic and non-neoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish publication-title: Veterinary Pathology contributor: fullname: Law – volume: 20 start-page: 933 year: 1999 end-page: 940 ident: bib25 article-title: Progression of hepatic neoplasia in medaka ( publication-title: Carcinogenesis contributor: fullname: Hinton – volume: 88 start-page: 319 year: 2005 end-page: 330 ident: bib35 article-title: Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver publication-title: Toxicological Sciences contributor: fullname: Corley-Smith – volume: 33 start-page: 75 year: 2005 end-page: 85 ident: bib39 article-title: A brief overview of non-neoplastic hepatic toxicity in fish publication-title: Toxicologic Pathology contributor: fullname: Wolfe – volume: 4 start-page: 253 year: 2002 end-page: 263 ident: bib3 article-title: Differential effect of chronic aflatoxin B1 intoxication on the growth performance and incidence of hepatic lesions in triploid and diploid rainbow trout ( publication-title: Archivos de Medicina Veterinária contributor: fullname: Hernandez-Blazquez – volume: 4 start-page: 253 year: 2002 ident: 10.1016/j.jcpa.2013.07.003_bib3 article-title: Differential effect of chronic aflatoxin B1 intoxication on the growth performance and incidence of hepatic lesions in triploid and diploid rainbow trout (Oncorhynchus mykiss) publication-title: Archivos de Medicina Veterinária contributor: fullname: Arana – volume: 25 start-page: 319 year: 2011 ident: 10.1016/j.jcpa.2013.07.003_bib34 article-title: Animal models for the study of hepatic fibrosis publication-title: Best Practice and Research in Clinical Gastroenterology doi: 10.1016/j.bpg.2011.02.004 contributor: fullname: Starkel – volume: 31 start-page: 58 issue: Suppl. 1 year: 2003 ident: 10.1016/j.jcpa.2013.07.003_bib38 article-title: The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters publication-title: Toxicologic Pathology contributor: fullname: Williams – volume: 50 start-page: 1174 year: 2009 ident: 10.1016/j.jcpa.2013.07.003_bib19 article-title: Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis publication-title: Journal of Hepatology doi: 10.1016/j.jhep.2009.01.028 contributor: fullname: Li – volume: 6 start-page: 203 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib27 article-title: The role of the myofibroblast in tumor stroma remodeling publication-title: Cell Adhesion and Migration doi: 10.4161/cam.20377 contributor: fullname: Otranto – volume: 19 start-page: 237 year: 1991 ident: 10.1016/j.jcpa.2013.07.003_bib10 article-title: Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model publication-title: Toxicologic Pathology doi: 10.1177/019262339101900306 contributor: fullname: Couch – volume: 207 start-page: 151 year: 2011 ident: 10.1016/j.jcpa.2013.07.003_bib21 article-title: Experimental study of non-alcoholic fatty liver disease (NAFLD) on a model of starving chickens: is generalization of steatosis accompanied by fibrosis of the liver tissue? publication-title: Pathology Research and Practice doi: 10.1016/j.prp.2010.12.002 contributor: fullname: Makovicky – volume: 88 start-page: 125 year: 2008 ident: 10.1016/j.jcpa.2013.07.003_bib12 article-title: Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver publication-title: Physiology Reviews doi: 10.1152/physrev.00013.2007 contributor: fullname: Friedman – volume: 6 start-page: 54 year: 1986 ident: 10.1016/j.jcpa.2013.07.003_bib41 article-title: Periductal fibrosis and lipocytes (fat-storing cells or Ito cells) during biliary atresia in the lamprey publication-title: Hepatology doi: 10.1002/hep.1840060111 contributor: fullname: Yamamoto – volume: 72 start-page: 22 year: 1989 ident: 10.1016/j.jcpa.2013.07.003_bib33 article-title: Survey of aflatoxins, ochratoxin A, zearalenone and sterigmatocystin in some Brazilian foods by using multi-toxin thin-layer chromatographic method publication-title: Journal of the Association of Official Analytical Chemists contributor: fullname: Soares – volume: 23 start-page: 447 year: 1995 ident: 10.1016/j.jcpa.2013.07.003_bib15 article-title: Carcinogenicity of dietary dimethylnitrosomorpholine, N-methyl-N′-nitro-N-nitrosoguanidine, and dibromoethane in rainbow trout publication-title: Toxicologic Pathology doi: 10.1177/019262339502300402 contributor: fullname: Hendricks – volume: 49 start-page: 372 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib17 article-title: Neoplastic and non-neoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish publication-title: Veterinary Pathology doi: 10.1177/0300985811409443 contributor: fullname: Hobbie – volume: 115 start-page: 209 year: 2005 ident: 10.1016/j.jcpa.2013.07.003_bib5 article-title: Liver fibrosis publication-title: Journal of Clinical Investigation doi: 10.1172/JCI24282 contributor: fullname: Bataller – volume: 88 start-page: 319 year: 2005 ident: 10.1016/j.jcpa.2013.07.003_bib35 article-title: Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver publication-title: Toxicological Sciences doi: 10.1093/toxsci/kfi309 contributor: fullname: Tilton – volume: 4 start-page: 709 year: 1984 ident: 10.1016/j.jcpa.2013.07.003_bib42 article-title: Immunocytochemical detection of desmin in fat-storing cells (Ito cells) publication-title: Hepatology doi: 10.1002/hep.1840040425 contributor: fullname: Yokoi – volume: 18 start-page: 155 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib1 article-title: Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches publication-title: Saudi Journal of Gastroenterology doi: 10.4103/1319-3767.96445 contributor: fullname: Ahmad – volume: 155 start-page: 121 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib37 article-title: The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention publication-title: Comparative Biochemistry and Physiology Part C contributor: fullname: Williams – volume: 297 start-page: G1093 year: 2009 ident: 10.1016/j.jcpa.2013.07.003_bib9 article-title: Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis publication-title: American Journal of Physiology: Gastrointestinal and Liver Physiology contributor: fullname: Choi – volume: 26 start-page: 1458 year: 1997 ident: 10.1016/j.jcpa.2013.07.003_bib22 article-title: Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor publication-title: Hepatology doi: 10.1002/hep.510260612 contributor: fullname: Neaud – volume: 31 start-page: 751 year: 2011 ident: 10.1016/j.jcpa.2013.07.003_bib2 article-title: Evaluation of the efficacy of hydrated sodium aluminosilicate in the prevention of aflatoxin-induced hepatic cancer in rainbow trout publication-title: Pesquisa Veterinária Brasileira doi: 10.1590/S0100-736X2011000900005 contributor: fullname: Arana – volume: 46 start-page: 443 year: 2000 ident: 10.1016/j.jcpa.2013.07.003_bib6 article-title: Is liver fibrosis reversible? publication-title: Gut doi: 10.1136/gut.46.4.443 contributor: fullname: Benyon – volume: 24 start-page: 877 year: 2000 ident: 10.1016/j.jcpa.2013.07.003_bib7 article-title: Cirrhosis: forever? publication-title: Gastroenterologie Clinique et Biologique contributor: fullname: Bioulac-Sage – volume: 33 start-page: 75 year: 2005 ident: 10.1016/j.jcpa.2013.07.003_bib39 article-title: A brief overview of non-neoplastic hepatic toxicity in fish publication-title: Toxicologic Pathology doi: 10.1080/01926230590890187 contributor: fullname: Wolf – volume: 38 start-page: 53 year: 2007 ident: 10.1016/j.jcpa.2013.07.003_bib43 article-title: The diffuse stellate cell system publication-title: Journal of Molecular Histology doi: 10.1007/s10735-007-9078-5 contributor: fullname: Zhao – start-page: 141 year: 1998 ident: 10.1016/j.jcpa.2013.07.003_bib16 article-title: Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses contributor: fullname: Hinton – volume: 27 start-page: 65 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib18 article-title: What’s new in liver fibrosis? The origin of myofibroblasts in liver fibrosis publication-title: Journal of Gastroenterology and Hepatology doi: 10.1111/j.1440-1746.2011.07002.x contributor: fullname: Iwaisako – volume: 20 start-page: 933 year: 1999 ident: 10.1016/j.jcpa.2013.07.003_bib25 article-title: Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine publication-title: Carcinogenesis doi: 10.1093/carcin/20.6.933 contributor: fullname: Okihiro – volume: 28 start-page: 342 year: 2000 ident: 10.1016/j.jcpa.2013.07.003_bib26 article-title: Partial hepatectomy and bile duct ligation in rainbow trout, (Oncorhynchus mykiss). Histologic, immunohistochemical and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasia publication-title: Toxicologic Pathology doi: 10.1177/019262330002800215 contributor: fullname: Okihiro – volume: 28 start-page: 223 year: 2012 ident: 10.1016/j.jcpa.2013.07.003_bib29 article-title: Complications of cirrhosis publication-title: Current Opinion in Gastroenterology doi: 10.1097/MOG.0b013e328351d003 contributor: fullname: Rahimi – volume: 65 start-page: 321 year: 1984 ident: 10.1016/j.jcpa.2013.07.003_bib14 article-title: Histological progression of hepatic neoplasia in rainbow trout (Salmo gairdneri) publication-title: National Cancer Institute Monographs contributor: fullname: Hendricks – volume: 79 start-page: 297 year: 1987 ident: 10.1016/j.jcpa.2013.07.003_bib11 article-title: N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow (Cyprinodon variegatus) neoplasms and related lesions compared with mammalian lesions publication-title: Journal of the National Cancer Institute contributor: fullname: Couch – volume: 104 start-page: 5 year: 1996 ident: 10.1016/j.jcpa.2013.07.003_bib4 article-title: Fish models for environmental carcinogenesis: the rainbow trout publication-title: Environmental Health Perspective contributor: fullname: Bailey – volume: 41 start-page: 744 year: 2013 ident: 10.1016/j.jcpa.2013.07.003_bib36 article-title: Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury publication-title: Toxicologic Pathology doi: 10.1177/0192623312464308 contributor: fullname: Van Wettere – volume: 32 start-page: 425 year: 2003 ident: 10.1016/j.jcpa.2013.07.003_bib24 article-title: Idiopathic hepatic fibrosis with cholestasis in broiler chickens: immunohistochemistry of hepatic stellate cells publication-title: Avian Pathology contributor: fullname: Ochiai – volume: 243 start-page: 11 year: 2008 ident: 10.1016/j.jcpa.2013.07.003_bib30 article-title: Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish, Danio rerio publication-title: Toxicology doi: 10.1016/j.tox.2007.09.007 contributor: fullname: Rekha – volume: 16 start-page: 1059 year: 1995 ident: 10.1016/j.jcpa.2013.07.003_bib8 article-title: Expression of actin and desmin in experimentally induced hepatic lesions and neoplasm from medaka (Oryzias Latipes) publication-title: Carcinogenesis doi: 10.1093/carcin/16.5.1059 contributor: fullname: Bunton – volume: 3 start-page: 157 year: 2011 ident: 10.1016/j.jcpa.2013.07.003_bib20 article-title: Liver development and cancer formation in zebrafish publication-title: Birth Defects Research (Part C) doi: 10.1002/bdrc.20205 contributor: fullname: Lu – volume: 275 start-page: 35565 year: 2000 ident: 10.1016/j.jcpa.2013.07.003_bib23 article-title: Paradoxical pro-invasive effect of the serine proteinase inhibitor tissue factor pathway inhibitor-2 on human hepatocellular carcinoma cells publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M006101200 contributor: fullname: Neaud – volume: 29 start-page: 58 year: 2008 ident: 10.1016/j.jcpa.2013.07.003_bib28 article-title: Myofibroblast-like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario publication-title: Molecular Aspects of Medicine doi: 10.1016/j.mam.2007.09.002 contributor: fullname: Parola – volume: 138 start-page: 1233 year: 1991 ident: 10.1016/j.jcpa.2013.07.003_bib31 article-title: Modulation of alpha-smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers publication-title: American Journal of Pathology contributor: fullname: Schmitt-Gräff – volume: 66 start-page: 437 year: 2003 ident: 10.1016/j.jcpa.2013.07.003_bib32 article-title: The expression of cytokeratin in hepatic stellate cells of the cod publication-title: Archives of Histology and Cytology doi: 10.1679/aohc.66.437 contributor: fullname: Senda – volume: 112 start-page: 1290 year: 1997 ident: 10.1016/j.jcpa.2013.07.003_bib40 article-title: Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma publication-title: Gastroenterology doi: 10.1016/S0016-5085(97)70143-4 contributor: fullname: Yamamoto |
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| Snippet | In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts... Summary In mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic... |
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| SubjectTerms | Aflatoxin B1 Animals Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology fish hepatocarcinogenesis Immunohistochemistry Liver - metabolism Liver - pathology liver fibrosis myofibroblast Myofibroblasts - metabolism Myofibroblasts - pathology Oncorhynchus mykiss Teleostei |
| Title | Immunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss) |
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