Testicular sperm aneuploidy in non-obstructive azoospermic patients

• Published in: Human reproduction (Oxford) Vol. 27; no. 7; pp. 2233 - 2239
• Main Authors: Vozdova, M., Heracek, J., Sobotka, V., Rubes, J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2012
• Subjects: Adult; Aged; Aneuploidy; Azoospermia - genetics; Biological and medical sciences; Children; chromosome 13; chromosome 15; Chromosome Aberrations; Chromosome Mapping; Chromosomes; Diploidy; Embryo Transfer; Fluorescence; Fluorescence in situ hybridization; General aspects. Genetic counseling; Genetic counselling; Genetic screening; Gynecology. Andrology. Obstetrics; Humans; In Situ Hybridization, Fluorescence; Male; Male genital diseases; Medical genetics; Medical sciences; Meiosis; Middle Aged; Non tumoral diseases; Reproduction; Risk; Sperm; Spermatozoa - pathology; Testes; Testis - pathology; aneuploidy; FISH; non-obstructive azoospermia; testicular sperm; Chromosomal aberration; Human; Spermatozoa; Semen; Aneuploidy; Germinal cell; Testicle; Male genital system; Azoospermia; Genetic counseling; Male sterility; Detection; Male genital diseases

BACKGROUND Non-obstructive azoospermic (NOA) men can father children after testicular sperm extraction (TESE). Previous studies suggest that they may be at risk of producing chromosomally abnormal spermatozoa, but the number of sperm analysed per patient was usually very low. METHODS Multicolour flu...