Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals

• Published in: Development (Cambridge) Vol. 146; no. 6
• Main Authors: Lu, Hao, Anujan, Priyanka, Zhou, Feng, Zhang, Yiliu, Chong, Yan Ling, Bingle, Colin D, Roy, Sudipto
• Format: Journal Article
• Language: English
• Published: England 15.03.2019
• Subjects: Animals; Basal Bodies - physiology; Carrier Proteins - physiology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Cycle Proteins - physiology; Cell Differentiation; Cell Nucleus - physiology; Cilia - physiology; Ciliopathies; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Nuclear Proteins - genetics; Nuclear Proteins - physiology; Protein Domains; Zebrafish; E2F; Multiciliated cell; GMNC; MCIDAS; Deuterosome; Cilia

Motile cilia on multiciliated cells (MCCs) function in fluid clearance over epithelia. Studies with embryos and individuals with the congenital respiratory disorder reduced generation of multiple motile cilia (RGMC), have implicated the nuclear protein MCIDAS (MCI), in the transcriptional regulation...