Deoxyshikonin Mediates Heme Oxygenase-1 Induction and Apoptotic Response via p38 Signaling in Tongue Cancer Cell Lines

• Published in: International journal of molecular sciences Vol. 23; no. 13; p. 7115
• Main Authors: Chuang, Chun-Yi, Lin, Chiao-Wen, Su, Chun-Wen, Chen, Yi-Tzu, Yang, Wei-En, Yang, Shun-Fa, Su, Shih-Chi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.07.2022; MDPI
• Subjects: Apoptosis; Cancer therapies; Cell cycle; Chemotherapy; Colorectal cancer; Disease; Kinases; Leukemia; Lung cancer; Medical prognosis; Oral cancer; Phosphorylation; Phytochemicals; Proteins; Radiation therapy; Squamous cell carcinoma; Tongue

Deoxyshikonin (DSK), a phytochemical constituent, has been documented to elicit various oncostatic properties alone or in combination with established therapeutics. However, its role in restraining oral squamous cell carcinoma (OSCC) is mostly unclear. Here, we examined the tumor-suppressive effect...