TAP1 and TAP2 genes in nickel allergy

• Published in: International archives of allergy and immunology Vol. 114; no. 1; p. 94
• Main Authors: Silvennoinen-Kassinen, S, Ikäheimo, I, Tiilikainen, A
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.1997
• Subjects: Alleles; Antigen Presentation - genetics; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette, Sub-Family B, Member 3; Case-Control Studies; Dermatitis, Allergic Contact - genetics; Dermatitis, Allergic Contact - immunology; Gene Frequency; Histocompatibility Antigens Class I - metabolism; HLA Antigens - metabolism; Humans; Nickel - adverse effects; Phenotype

The study was undertaken to see whether TAP1 and TAP2 (transporter associated with antigen processing) genes are involved in susceptibility to nickel allergy. The products of these genes are important in antigen transport and processing, making them candidates for disease susceptibility. Fifty-five...