Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis

• Published in: Cell calcium (Edinburgh) Vol. 33; no. 5-6; pp. 357 - 373
• Main Authors: Vanden Abeele, F, Shuba, Y, Roudbaraki, M, Lemonnier, L, Vanoverberghe, K, Mariot, P, Skryma, R, Prevarskaya, N
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.05.2003
• Subjects: Biomarkers; Calcium - metabolism; Calcium Channels - genetics; Calcium Channels - metabolism; Cancer; Cellular Biology; Electrophysiology; Endoplasmic Reticulum - metabolism; Epithelial Cells - metabolism; Epithelial Cells - pathology; Human health and pathology; Humans; Kinetics; Life Sciences; Male; Oligonucleotides, Antisense - pharmacology; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; RNA, Messenger - drug effects; Subcellular Processes; TRPC Cation Channels; TRPV Cation Channels; Tumor Cells, Cultured; Urology and Nephrology

Ca2+ homeostasis mechanisms, in which the Ca2+ entry pathways play a key role, are critically involved in both normal function and cancerous transformation of prostate epithelial cells. Here, using the lymph node carcinoma of the prostate (LNCaP) cell line as a major experimental model, we character...