Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs

• Published in: International journal of molecular sciences Vol. 23; no. 14; p. 7508
• Main Authors: Truong, Trang T. T., Bortolasci, Chiara C., Kidnapillai, Srisaiyini, Spolding, Briana, Panizzutti, Bruna, Liu, Zoe S. J., Kim, Jee Hyun, Dean, Olivia M., Richardson, Mark F., Berk, Michael, Walder, Ken
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06.07.2022; MDPI
• Subjects: Antipsychotics; Apoptosis; Brain; Drugs; Gene expression; Genomes; Insulin; Kinases; Peptides; Potassium; Proteins; Psychotropic drugs; Schizophrenia; Signal transduction

There is little understanding of the underlying molecular mechanism(s) involved in the clinical efficacy of antipsychotics for schizophrenia. This study integrated schizophrenia-associated transcriptional perturbations with antipsychotic-induced gene expression profiles to detect potentially relevan...