BMI1 gene expression in myeloid leukemias and its impact on prognosis

• Published in: Blood cells, molecules, & diseases Vol. 53; no. 4; pp. 194 - 198
• Main Authors: Saudy, Niveen S., Fawzy, Iman M., Azmy, Emad, Goda, Enas F., Eneen, Asmaa, Abdul Salam, Eman M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Adult; AML; BMI1; Case-Control Studies; CML; Female; Gene Expression; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; Male; Middle Aged; Multivariate Analysis; Myeloid; Polycomb; Polycomb Repressive Complex 1 - genetics; Prognosis; Survival Analysis; AML; Polycomb; CML; Myeloid; BMI1; Leukemia

BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis. This study was aimed to investigate the expression and impact...