BMI1 gene expression in myeloid leukemias and its impact on prognosis

BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis. This study was aimed to investigate the expression and impact...

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Published in	Blood cells, molecules, & diseases Vol. 53; no. 4; pp. 194 - 198
Main Authors	Saudy, Niveen S., Fawzy, Iman M., Azmy, Emad, Goda, Enas F., Eneen, Asmaa, Abdul Salam, Eman M.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.12.2014
Subjects	Adult AML BMI1 Case-Control Studies CML Female Gene Expression Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Middle Aged Multivariate Analysis Myeloid Polycomb Polycomb Repressive Complex 1 - genetics Prognosis Survival Analysis AML Polycomb CML Myeloid BMI1 Leukemia
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Abstract	BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis. This study was aimed to investigate the expression and impact of BMI1 in myeloid leukemias. Expression levels of BMI1 in 100 acute myeloid leukemia (AML), 100 chronic myeloid leukemia (CML) patients and 20 healthy controls were measured by real time quantitative polymerase chain reaction (RQ-PCR). The results showed that the expression of BMI1 was significantly higher in AML and CML versus control subjects (p<0.001 for both). The 2-year overall and disease free survival rates were significantly lower in patients expressing higher BMI1. Multivariate analysis showed that BMI1 was independent prognostic factor for OS for AML cases (p=0.015, HR=3.204, 95% CI=1.250–8.212). Accelerated and blastic phases in CML cases expressed higher BMI1 than chronic phase (p<0.001). We concluded that detecting BMI1 is helpful for predicting the survival in AML patients and monitoring the aggressiveness and progression in patients with CML.
AbstractList	BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis. This study was aimed to investigate the expression and impact of BMI1 in myeloid leukemias. Expression levels of BMI1 in 100 acute myeloid leukemia (AML), 100 chronic myeloid leukemia (CML) patients and 20 healthy controls were measured by real time quantitative polymerase chain reaction (RQ-PCR). The results showed that the expression of BMI1 was significantly higher in AML and CML versus control subjects (p<0.001 for both). The 2-year overall and disease free survival rates were significantly lower in patients expressing higher BMI1. Multivariate analysis showed that BMI1 was independent prognostic factor for OS for AML cases (p=0.015, HR=3.204, 95% CI=1.250-8.212). Accelerated and blastic phases in CML cases expressed higher BMI1 than chronic phase (p<0.001). We concluded that detecting BMI1 is helpful for predicting the survival in AML patients and monitoring the aggressiveness and progression in patients with CML. BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis.BACKGROUNDBMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1 underwent proliferation arrest and showed signs of differentiation and apoptosis.This study was aimed to investigate the expression and impact of BMI1 in myeloid leukemias. Expression levels of BMI1 in 100 acute myeloid leukemia (AML), 100 chronic myeloid leukemia (CML) patients and 20 healthy controls were measured by real time quantitative polymerase chain reaction (RQ-PCR).AIMThis study was aimed to investigate the expression and impact of BMI1 in myeloid leukemias. Expression levels of BMI1 in 100 acute myeloid leukemia (AML), 100 chronic myeloid leukemia (CML) patients and 20 healthy controls were measured by real time quantitative polymerase chain reaction (RQ-PCR).The results showed that the expression of BMI1 was significantly higher in AML and CML versus control subjects (p<0.001 for both). The 2-year overall and disease free survival rates were significantly lower in patients expressing higher BMI1. Multivariate analysis showed that BMI1 was independent prognostic factor for OS for AML cases (p=0.015, HR=3.204, 95% CI=1.250-8.212). Accelerated and blastic phases in CML cases expressed higher BMI1 than chronic phase (p<0.001).RESULTSThe results showed that the expression of BMI1 was significantly higher in AML and CML versus control subjects (p<0.001 for both). The 2-year overall and disease free survival rates were significantly lower in patients expressing higher BMI1. Multivariate analysis showed that BMI1 was independent prognostic factor for OS for AML cases (p=0.015, HR=3.204, 95% CI=1.250-8.212). Accelerated and blastic phases in CML cases expressed higher BMI1 than chronic phase (p<0.001).We concluded that detecting BMI1 is helpful for predicting the survival in AML patients and monitoring the aggressiveness and progression in patients with CML.CONCLUSIONWe concluded that detecting BMI1 is helpful for predicting the survival in AML patients and monitoring the aggressiveness and progression in patients with CML.
Author	Azmy, Emad Fawzy, Iman M. Goda, Enas F. Eneen, Asmaa Saudy, Niveen S. Abdul Salam, Eman M.
Author_xml	– sequence: 1 givenname: Niveen S. surname: Saudy fullname: Saudy, Niveen S. organization: Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 2 givenname: Iman M. surname: Fawzy fullname: Fawzy, Iman M. email: hematologyaml@yahoo.com organization: Laboratory Medicine Department, Mansoura Fever Hospital, Ministry of Health, Mansoura, Egypt – sequence: 3 givenname: Emad surname: Azmy fullname: Azmy, Emad organization: Clinical Hematology Depatment, Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 4 givenname: Enas F. surname: Goda fullname: Goda, Enas F. organization: Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 5 givenname: Asmaa surname: Eneen fullname: Eneen, Asmaa organization: Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt – sequence: 6 givenname: Eman M. surname: Abdul Salam fullname: Abdul Salam, Eman M. organization: General Medicine, Faculty of Medicine, Azhar University, Cairo, Egypt
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25084695$$D View this record in MEDLINE/PubMed
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Keywords	AML Polycomb CML Myeloid BMI1 Leukemia
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Snippet	BMI1 is a polycomb group (PcG) protein and is overexpressed in leukemia. It plays a key role in the self-renewal of stem cells. Leukemic cells lacking BMI1...
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SubjectTerms	Adult AML BMI1 Case-Control Studies CML Female Gene Expression Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Middle Aged Multivariate Analysis Myeloid Polycomb Polycomb Repressive Complex 1 - genetics Prognosis Survival Analysis
Title	BMI1 gene expression in myeloid leukemias and its impact on prognosis
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