Diminished β-adrenoceptor-mediated relaxation of femoral arteries from young spontaneously hypertensive rats

• Published in: Autonomic neuroscience Vol. 87; no. 2; pp. 178 - 186
• Main Authors: Fujimoto, S, Fujimoto, K.S, Moriyama, A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 23.03.2001; Elsevier
• Subjects: Acetylcholine - pharmacology; Animals; Antihypertensive Agents - pharmacology; Arginine - pharmacology; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Blood Pressure - physiology; Body Weight - drug effects; Body Weight - physiology; Captopril; Captopril - pharmacology; Cardiology. Vascular system; Colforsin - pharmacology; Endothelium; Endothelium, Vascular - physiology; Experimental diseases; Femoral Artery - physiology; Male; Medical sciences; Nitro l-arginine; Nitroprusside - pharmacology; Norepinephrine - pharmacology; Potassium Channels - physiology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta - physiology; Spontaneously hypertensive rat (SHR); Vasoconstrictor Agents - pharmacology; Vasodilation - drug effects; Vasodilation - physiology; Vasodilator Agents - pharmacology; β-Adrenoceptor; β-Adrenoceptor; Captopril; Endothelium; Nitro l-arginine; Spontaneously hypertensive rat (SHR); Hypertension; Femoral artery; Rat; Rodentia; Cardiovascular disease; β-Adrenergic receptor; Muscular relaxation; Vertebrata; Mammalia; Animal; Nitric oxide

A β-adrenoceptor agonist, norepinephrine (NE)-induced relaxation in the presence of an α-adrenoceptor antagonist and indomethacin was investigated in isolated femoral arteries from 5-week-old Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). NE elicited endothelium-dependent and -in...