Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA

• Published in: Gene Vol. 542; no. 1; pp. 64 - 68
• Main Authors: Lu, Baocai, Li, Jing, Gao, Qingzu, Yu, Wenfa, Yang, Qinghui, Li, Xiaoyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.05.2014
• Subjects: Alcohol Drinking; alleles; Biomarkers, Tumor - genetics; breast neoplasms; Breast Neoplasms - genetics; Case-Control Studies; DNA Helicases - genetics; DNA repair; DNA Repair - genetics; DNA repair gene; DNA-Binding Proteins - genetics; drinking; Endonucleases - genetics; environmental factors; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Laryngeal cancer; laryngeal neoplasms; Laryngeal Neoplasms - epidemiology; Laryngeal Neoplasms - genetics; Male; Middle Aged; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Risk; Risk Factors; Single nucleotide polymorphism; Smoking; Transcription Factors - genetics; Xeroderma Pigmentosum Group A Protein - genetics; Xeroderma Pigmentosum Group D Protein - genetics; Laryngeal cancer; TCR; XPA; HRR; XPB; XPD; DNA repair gene; XPG; XPF; SNP; SSBR; HWE; 95% OR; SPSS; CI; BER; GGR; ERCC3; ERCC4; ERCC1; DNA; ERCC2; ERCC5; NER; Single nucleotide polymorphism; PCR

Because the molecular mechanisms underlying the development of laryngeal cancer are not well understood, we conducted a case–control study to determine the association between eight common SNPs in NER pathway genes and risk of laryngeal cancer, and the association between genetic polymorphisms and e...