SCARB1 rs5888 gene polymorphisms in coronary heart disease: A systematic review and a meta-analysis

• Published in: Gene Vol. 678; pp. 280 - 287
• Main Authors: Ma, Ruchao, Zhu, Xiaoyun, Yan, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2018
• Subjects: alleles; case-control studies; cholesterol; cohort studies; coronary disease; Coronary Disease - genetics; Coronary heart disease; Female; Genetic Association Studies; genetic polymorphism; Genetic Predisposition to Disease; high density lipoprotein; Humans; Male; males; Meta-analysis; Polymorphism, Single Nucleotide; Polymorphisms; risk; rs5888; SCARB1; Scavenger Receptors, Class B - genetics; Sex Characteristics; Systematic review; women; SCARB1; rs5888; NOS; OR; SNP; CI; Systematic review; Polymorphisms; Coronary heart disease; CHD; Meta-analysis

Studies have suggested that high-density lipoprotein (HDL) stimulates scavenger receptor class B type 1 (SR-B1) to promote hepatic uptake of cholesterol. SR-B1 is encoded by scavenger receptor class B member 1 (SCARB1) gene in human. A rare mutation in SCARB1 gene has been associated with coronary h...