Improved detection of recurrent bladder cancer using the bard bta stat test

• Published in: Urology (Ridgewood, N.J.) Vol. 50; no. 3; pp. 349 - 353
• Main Authors: Sarosdy, Michael F., Hudson, M'Liss A., Ellis, William J., Soloway, Mark S., White, Ralph deVere, Sheinfeld, Joel, Jarowenko, Mark V., Schellhammer, Paul F., Schervish, Ed W., Patel, Jay V., Chodak, Gerald W., Lamm, Donald L., Johnson, Robert D., Henderson, Mary, Adams, George, Blumenstein, Brent A., Thoelke, Kent R., Pfalzgraf, Randy D., Murchison, Heather A., Brunelle, Sharon L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1997; Elsevier Science
• Subjects: Aged; Aged, 80 and over; Antigens, Neoplasm - urine; Biological and medical sciences; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - urine; Neoplasm Staging; Nephrology. Urinary tract diseases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Sensitivity and Specificity; Tumors of the urinary system; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - urine; Urinary system; Urinary tract. Prostate gland; Human; Urine; Relapse; Urinary system disease; Immunoaffinity chromatography; Cytologic investigation; Colorimetry; Urinary tract disease; Malignant tumor; Medical screening; Sensitivity; Specificity; Urinary bladder; Bladder disease
• DOI: 10.1016/S0090-4295(97)00292-6
• ISSN: 0090-4295

Abstract To evaluate the BTA stat Test in the detection of recurrent bladder cancer. Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer. The BTA stat Test detected 147 (67%) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23%, the BTA Test 44%, and the BTA stat Test 58% for detection of recurrent cancer (P < 0.001, stat versus cytology). The specificity of the BTA stat Test was 72% for benign genitourinary disease and 95% in healthy volunteers. The BTA stat Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.