Mitomycin-C supplemented trabeculectomy, phacoemulsification, and foldable lens implantation

• Published in: Journal of cataract and refractive surgery Vol. 23; no. 4; pp. 565 - 569
• Main Authors: Yang, Kun-Jin, Moster, Marlene R., Azuara-Blanca, Augusto, Wilson, Richard P., Araujo, Silvana V., Schmidt, Courtland M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1997; Elsevier Science
• Subjects: Aged; Biological and medical sciences; Cataract - etiology; Cataract Extraction; Equipment Design; Female; Glaucoma and intraocular pressure; Humans; Intraocular Pressure; Lenses, Intraocular; Male; Medical sciences; Mitomycin - therapeutic use; Ophthalmology; Phacoemulsification; Postoperative Complications; Reoperation; Retrospective Studies; Trabeculectomy; Treatment Outcome; Visual Acuity; Antineoplastic agent; Human; Trabeculectomy; Cataract; Mitomycin; Phacoemulsification; Eye disease; Antibiotic; Chemotherapy; Lens disease; Surgical implantation; Glaucoma (eye); Surgery; Combined treatment; Intraocular lens; Anterior segment disease
• ISSN: 0886-3350; 1873-4502
• DOI: 10.1016/S0886-3350(97)80215-5

Purpose: To evaluate the outcome of combined mitomycin-C filtering surgery, phacoemulsification, and foldable intraocular lens (IOL) implantation. Setting: Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Methods: This retrospective study evaluated 182 eyes of 174 patients who had combined mitomycin-C trabeculectomy, phacoemulsification, and insertion of a foldable IOL through a 3.5 mm incision. Success of the combined procedure was defined as intraocular pressure (IOP) below 21 mm Hg, with or without medications, and no serious complication. Success rates were calculated using the Kaplan-Meier actuarial method. Results: Mean follow-up was 16.7 months ± 5.4 (SD). The probability of success at 6, 12, 18, and 24 months was 98.3, 95.6, 90.6, and 88.0%, respectively. When compared with preoperatively, visual acuity improved one or more lines in 148 eyes (81.3%) and worsened one or more lines in 15 (8.2%); 111 eyes (61.0%) achieved visual acuity of 20/40 or better. The most frequent complication was posterior capsule opacification requiring capsulotomy, which occurred in 22 cases (12.0%). Conclusion: The 1 year and 2 year IOP control rate of combined mitomycin-C filtering procedures and phacoemulsification in glaucoma patients was high.