A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease

A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer sev...

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Published inJournal of laboratory medicine Vol. 49; no. 4; pp. 149 - 154
Main Authors Boulassel, Mohamed-Rachid, Abdellatif, Hussein, Al-Falahi, Karima, Al-Hashmi, Fatma, Bouchareb, Yassine, Al-Abri, Buthaina, Al-Jahdhami, Habib
Format Journal Article
LanguageEnglish
Published De Gruyter 26.08.2025
Subjects
automation
ristocetin co-factor activity
von Willebrand disease
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Abstract A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer several advantages for routine testing. Herein the performance of the automated Sysmex CS2000/2100i analyzer was compared to the manual aggregometer Chrono-log 700 for assessing VWF:Co activity in patients suspected of having von Willebrand disease (VWD).
AbstractList A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual aggregometry technique is the reference method, even having high inter-laboratory variability. The automated coagulation analyzers offer several advantages for routine testing. Herein the performance of the automated Sysmex CS2000/2100i analyzer was compared to the manual aggregometer Chrono-log 700 for assessing VWF:Co activity in patients suspected of having von Willebrand disease (VWD).
Author Abdellatif, Hussein
Al-Falahi, Karima
Bouchareb, Yassine
Al-Hashmi, Fatma
Al-Abri, Buthaina
Boulassel, Mohamed-Rachid
Al-Jahdhami, Habib
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Snippet A variety of methods are currently used to measure von Willebrand factor (VWF) activity, but still the VWF ristocetin cofactor (VWF:RCo) assay using the manual...
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SubjectTerms automation
ristocetin co-factor activity
von Willebrand disease
Title A comparative study between the Chrono-log 700 and the Sysmex CS-2100i analyzers for assessing ristocetin cofactor activity in patients with von Willebrand disease
URI https://www.degruyter.com/doi/10.1515/labmed-2024-0160
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