Cytochrome P450 27C1 Level Dictates Lung Cancer Tumorigenicity and Sensitivity towards Multiple Anticancer Agents and Its Potential Interplay with the IGF-1R/Akt/p53 Signaling Pathway

• Published in: International journal of molecular sciences Vol. 23; no. 14; p. 7853
• Main Authors: Mo, Hai-Ying, Wei, Qi-Yao, Zhong, Qiu-Hua, Zhao, Xiao-Yun, Guo, Dan, Han, Jin, Noracharttiyapot, Wachiraporn, Visser, Lydia, van den Berg, Anke, Xu, Yan-Ming, Lau, Andy T. Y.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 16.07.2022; MDPI
• Subjects: Cell adhesion & migration; Cell growth; Cytochrome; Drugs; Fatty acids; Lung cancer; Phosphorylation; Protein expression; Proteins; Signal transduction

Cytochrome P450 enzymes (CYP450s) exert mighty catalytic actions in cellular metabolism and detoxication, which play pivotal roles in cell fate determination. Preliminary data shows differential expression levels of CYP27C1, one of the “orphan P450s” in human lung cancer cell lines. Here, we study t...