Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

• Published in: Advances in wound care (New Rochelle, N.Y.) Vol. 2; no. 4; p. 122
• Main Authors: Van De Water, Livingston, Varney, Scott, Tomasek, James J
• Format: Journal Article
• Language: English
• Published: United States 01.05.2013

Myofibroblasts are responsible for wound closure that occurs in healed acute wounds. However, their actions can result in disfiguring scar contractures, compromised organ function, and a tumor promoting stroma. Understanding the mechanisms regulating their contractile machinery, gene expression, and...