7-Nitroindazole: A selective inhibitor of penile erection: An in vivo study in a rat animal model

• Published in: Urology (Ridgewood, N.J.) Vol. 47; no. 1; pp. 93 - 96
• Main Authors: Spiess, Philippe E., Dion, Stéphane B., Zvara, Peter, Merlin, Scott L., Chan, Peter T.K., Brock, Gerald B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1996; Elsevier Science
• Subjects: Analysis of Variance; Animals; Biological and medical sciences; Blood Pressure - drug effects; Dose-Response Relationship, Drug; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Indazoles - pharmacology; Male; Mammalian male genital system; Morphology. Physiology; Penile Erection - drug effects; Penile Erection - physiology; Rats; Rats, Sprague-Dawley; Vertebrates: reproduction; Human; Animal model; Rat; Enzyme; Erection; Rodentia; Enzyme inhibitor; Male; Biological activity; Nitric-oxide synthase; Vertebrata; Mammalia; Oxidoreductases

The neuronal isoform of nitric oxide synthase (nNOS) has been localized in neurons innervating the penis and is believed to be an important mediator of erection. Using the selective inhibitor 7-nitroindazole (7-NI), we evaluated the possible role of nNOS in penile erection using a rat animal model....