Protease inhibitors: a therapeutic breakthrough for the treatment of patients with human immunodeficiency virus
As one of the largest growing classes of antiretroviral drugs, protease inhibitors are promising agents for the management of patients infected with the human immuno deficiency virus (HIV). We reviewed the literature and compared efficacy, dosing, side effects, and drug-interaction profiles of the p...
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| Published in | Clinical therapeutics Vol. 19; no. 2; pp. 187 - 214 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Belle Mead, NJ
EM Inc USA
01.03.1997
Excerpta Medica |
| Subjects | |
| Online Access | Get full text |
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| Abstract | As one of the largest growing classes of antiretroviral drugs, protease inhibitors are promising agents for the management of patients infected with the human immuno deficiency virus (HIV). We reviewed the literature and compared efficacy, dosing, side effects, and drug-interaction profiles of the protease inhibitors saquinavir, ritonavir, indinavir, and nelfinavir. We addressed the used of these antiprotease agents as monotherapy versus use in combination therapy with other antiretroviral medications, and the potential for HIV to develop resistance to this drug class. We also discussed therapy with dual protease inhibitors and the use of protease inhibitors in pregnant or lactating women and in pediatric patients. Finally, we examined case reports of the addition of protease inhibitors to an antiretroviral regimen that ultimately decreases or reverses opportunistic infections |
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| AbstractList | As one of the largest growing classes of antiretroviral drugs, protease inhibitors are promising agents for the management of patients infected with the human immunodeficiency virus (HIV). We reviewed the literature and compared efficacy, dosing, side effects, and drug-interaction profiles of the protease inhibitors saquinavir, ritonavir, indinavir, and nelfinavir. We addressed the use of these antiprotease agents as monotherapy versus use in combination therapy with other antiretroviral medications, and the potential for HIV to develop resistance to this drug class. We also discussed therapy with dual protease inhibitors and the use of protease inhibitors in pregnant or lactating women and in pediatric patients. Finally, we examined case reports of the addition of protease inhibitors to an antiretroviral regimen that ultimately decreases or reverses opportunistic infections. As one of the largest growing classes of antiretroviral drugs, protease inhibitors are promising agents for the management of patients infected with the human immuno deficiency virus (HIV). We reviewed the literature and compared efficacy, dosing, side effects, and drug-interaction profiles of the protease inhibitors saquinavir, ritonavir, indinavir, and nelfinavir. We addressed the used of these antiprotease agents as monotherapy versus use in combination therapy with other antiretroviral medications, and the potential for HIV to develop resistance to this drug class. We also discussed therapy with dual protease inhibitors and the use of protease inhibitors in pregnant or lactating women and in pediatric patients. Finally, we examined case reports of the addition of protease inhibitors to an antiretroviral regimen that ultimately decreases or reverses opportunistic infections |
| Author | Lewis, James S. Terriff, Colleen M. Coulston, Daniel R. Garrison, Mark W. |
| Author_xml | – sequence: 1 givenname: James S. surname: Lewis fullname: Lewis, James S. organization: Washington State University, College of Pharmacy, Deaconess Medical Center, Spokane, Washington U.S.A – sequence: 2 givenname: Colleen M. surname: Terriff fullname: Terriff, Colleen M. organization: Washington State University, College of Pharmacy, Deaconess Medical Center, Spokane, Washington U.S.A – sequence: 3 givenname: Daniel R. surname: Coulston fullname: Coulston, Daniel R. organization: Internal Medicine, Deaconess Medical Center, Spokane, Washington U.S.A – sequence: 4 givenname: Mark W. surname: Garrison fullname: Garrison, Mark W. organization: Washington State University, College of Pharmacy, Deaconess Medical Center, Spokane, Washington U.S.A |
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| Keywords | human immunodeficiency virus protease inhibitors indinavir nelfinavir saquinavir ritonavir Human Immunopathology Monograph Enzyme Enzyme inhibitor AIDS Review Immune deficiency Infection Peptidases Chemotherapy Treatment Viral disease Hydrolases Antiviral |
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delavirdine in healthy volunteers publication-title: Program and Abstracts of the Fourth Conference on Retroviruses and Opportunistic Infections contributor: fullname: Ferry – year: 15181996 ident: 10.1016/S0149-2918(97)80110-5_BIB51 article-title: Absence of interaction between indinavir and fluconazole: A pharmacokinetic study in HIV patients publication-title: Program and Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology contributor: fullname: De Wit – volume: 8 start-page: 1065 year: 1992 ident: 10.1016/S0149-2918(97)80110-5_BIB60 article-title: HIV drug resistance publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.1992.8.1065 contributor: fullname: Richman – year: 22261997 ident: 10.1016/S0149-2918(97)80110-5_BIB49 article-title: Effect of nevirapine on pharmacokinetics of indinavir and ritonavir in HIV-1 patients publication-title: Program and Abstracts of the Fourth Conference on Retroviruses and Opportunistic Infections contributor: fullname: Murphy – year: 22261997 ident: 10.1016/S0149-2918(97)80110-5_BIB77 article-title: Salvage therapy using the combination of ritonavir and saquinavir in patients with advanced HIV infection publication-title: Program and Abstracts of the Fourth Conference on Retroviruses and Opportunistic Infections contributor: fullname: Steinhart – volume: 2 year: 1996 ident: 10.1016/S0149-2918(97)80110-5_BIB10 article-title: How the protease inhibitors work: Their mechanism of action, with schematic color illustrations publication-title: HIV Newsline – year: 7121996 ident: 10.1016/S0149-2918(97)80110-5_BIB21 article-title: Assessment of single- and multiple-dose interactions between ritonavir and saquinavir publication-title: Program and Abstracts of the XI International Conference on AIDS contributor: fullname: Hsu – year: 15181996 ident: 10.1016/S0149-2918(97)80110-5_BIB24 article-title: Rifabutin reduces saquinavir plasma levels in HIV-infected 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| SubjectTerms | AIDS-Related Opportunistic Infections - drug therapy Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Interactions Drug Therapy, Combination Female HIV Infections - drug therapy human immunodeficiency virus Humans indinavir Lactation - drug effects Medical sciences nelfinavir Pharmacology. Drug treatments Pregnancy protease inhibitors Protease Inhibitors - adverse effects Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use ritonavir saquinavir |
| Title | Protease inhibitors: a therapeutic breakthrough for the treatment of patients with human immunodeficiency virus |
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