TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK–JAK interaction

• Published in: International immunology Vol. 30; no. 7; pp. 291 - 299
• Main Authors: Kimura, Masanobu, Nagashima, Hiroyuki, Okuyama, Yuko, Ishii, Naoto, So, Takanori
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 26.06.2018
• Subjects: cytokine; Janus kinase; protein interaction; signal transduction; TNF receptor-associated factor

TRAF-family members prevent IL-6R-mediated JAK-JAK interaction Abstract Tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 constitutively bind to glycoprotein 130 kDa (gp130) and inhibit IL-6-driven activation of signal transducer and activator of transcription 3 (STAT3) in CD4+ T...