Prolactin as an inhibitor of granulosa cell luteinization: implications for hyperprolactinemia-associated luteal phase dysfunction

• Published in: Fertility and sterility Vol. 48; no. 1; pp. 131 - 139
• Main Authors: Adashi, Eli Y., Resnick, Carol E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1987; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Corpus Luteum Maintenance; Female; Fundamental and applied biological sciences. Psychology; Granulosa Cells - drug effects; Hormone metabolism and regulation; Humans; Hyperprolactinemia - physiopathology; Luteal Phase; Mammalian female genital system; Pregnancy; Progesterone - biosynthesis; Prolactin - pharmacology; Rats; Rats, Inbred Strains; Receptors, LH - drug effects; Vertebrates: reproduction; Cell culture; Animal model; Menstruation disorders; Rat; Hyperprolactinemia; Rodentia; Etiopathogenesis; Gonadotropin; Luteinization; Glycoprotein hormone; In vitro; Biological activity; Inadequate luteal phase; In vivo; Vertebrata; Biological fixation; Mammalia; Prolactin; Hormonal regulation; FSH; Steroidogenesis; Granulosa; Progesterone; LH

Chronic and transient hyperprolactinemia have been associated with luteal phase dysfunction in both spontaneously cycling women and those subjected to ovarian hyperstimulation by exogenous gonadotropins. It is the objective of the in vitro and in vivo studies reported herein to examine the possibili...