Elevation of plasma podoplanin in Kawasaki disease

Kawasaki disease (KD) is a systemic vasculitis that results in abnormalities in the coronary arteries. Podoplanin (PDPN) and its receptor C-type lectin-like receptor 2 (CLEC-2) are involved in inflammatory hemostasis and have also been proved to be effective predictive markers for early evaluation o...

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Bibliographic Details
Published inJournal of laboratory medicine Vol. 49; no. 4; pp. 163 - 169
Main Authors Xu, Ling, Li, Wei, Geng, Zhimin, Peng, Zhaoyang, Sun, Anna, Qin, Wenjun, Xie, Chunhong, Gong, Fangqi, Shen, Hongqiang
Format Journal Article
LanguageEnglish
Published De Gruyter 26.08.2025
Subjects
coagulation
coronary artery lesions
inflammation indicators
Kawasaki disease
PDPN
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Summary:Kawasaki disease (KD) is a systemic vasculitis that results in abnormalities in the coronary arteries. Podoplanin (PDPN) and its receptor C-type lectin-like receptor 2 (CLEC-2) are involved in inflammatory hemostasis and have also been proved to be effective predictive markers for early evaluation of sepsis and coagulation. This study aimed to investigate the expression of PDPN and its receptor CLEC-2 in the patients with KD, and evaluate the relationship between PDPN and clinical laboratory parameters.
ISSN:2567-9430
2567-9449
DOI:10.1515/labmed-2024-0214