Exosomal long non-coding RNA LIPCAR derived from oxLDL-treated THP-1 cells regulates the proliferation of human umbilical vein endothelial cells and human vascular smooth muscle cells

• Published in: Biochemical and biophysical research communications Vol. 575; pp. 65 - 72
• Main Authors: Hu, Nan, Zeng, Xixi, Tang, Feifei, Xiong, Sizheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2021
• Subjects: apoptosis; Apoptosis - physiology; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - genetics; Atherosclerosis - pathology; biomarkers; Cell Movement - physiology; Cell Proliferation - physiology; cyclin-dependent kinase; Exosome; Exosomes; Foam cell; foam cells; Human Umbilical Vein Endothelial Cells; Humans; Knockdown; Lipoproteins, LDL - pharmacology; lncRNA LIPCAR; low density lipoprotein; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; non-coding RNA; oxidation; proliferating cell nuclear antigen; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; smooth muscle; THP-1 Cells; Knockdown; Foam cell; Exosome; lncRNA LIPCAR; Atherosclerosis

It has been reported that long non-coding RNA (lncRNA) LIPCAR is involved in the progression of atherosclerosis. However, the mechanism underlying the effects of LIPCAR on regulating the occurrence and development of atherosclerosis remains unclear. Reverse transcription-quantitative PCR was perform...