LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia

• Published in: Biochemical and biophysical research communications Vol. 604; pp. 43 - 50
• Main Authors: Chen, Yaxin, Meng, Yingying, Yu, Yanhong, Li, Wen, Shen, Yongmei, Li, Shanshan, Chang, Ying, Sun, Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.05.2022
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Cell Line, Tumor; Cell Movement; Female; Hippo pathway; Humans; LIM Domain Proteins - genetics; LIM Domain Proteins - metabolism; LMO2; Placenta - metabolism; Placentation; pre-eclampsia; Pre-Eclampsia - metabolism; prediction; Preeclampsia; Pregnancy; Proto-Oncogene Proteins - metabolism; pseudopodia; Trophoblast; Trophoblasts - metabolism; WAVE complex; Wnt pathway; STB; NCKAP1; EVT; Wnt pathway; LMO2; Trophoblast; iEVT; CTB; eEVT; WAVE2; WAVE complex; Hippo pathway; PE; Preeclampsia

Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous troph...