LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia

Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous troph...

Full description

Saved in:
Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 604; pp. 43 - 50
Main Authors Chen, Yaxin, Meng, Yingying, Yu, Yanhong, Li, Wen, Shen, Yongmei, Li, Shanshan, Chang, Ying, Sun, Wei
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.05.2022
Subjects
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Cell Line, Tumor
Cell Movement
Female
Hippo pathway
Humans
LIM Domain Proteins - genetics
LIM Domain Proteins - metabolism
LMO2
Placenta - metabolism
Placentation
pre-eclampsia
Pre-Eclampsia - metabolism
prediction
Preeclampsia
Pregnancy
Proto-Oncogene Proteins - metabolism
pseudopodia
Trophoblast
Trophoblasts - metabolism
WAVE complex
Wnt pathway
STB
NCKAP1
EVT
Wnt pathway
LMO2
Trophoblast
iEVT
CTB
eEVT
WAVE2
WAVE complex
Hippo pathway
PE
Preeclampsia
Online AccessGet full text

Cover

Abstract Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical. [Display omitted] •Compared with normal placenta, LMO2 showed decreased expression level in both CTBs and EVTs in preeclampsia placentas.•LMO2 increased cell migration in iEVT derived HTR-8/SVneo cells via targeting to NCKAP1.•LMO2 promoted cell proliferation in CTB derived JEG-3 cells via targeting to beta-Catenin.
AbstractList Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical.Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical.
Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical.
Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical.
Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and spiral artery remodeling. In this study, we found that LMO2 level was decreased in both cytotrophoblast (CTB) and interstitial extravillous trophoblast (iEVT) in human PE placentas, and LMO2 selectively promoted cell migration in iEVT derived HTR-8/SVneo cells whereas increased proliferation in CTB derived JEG-3 cells. In mechanism, LMO2 interacted with NCKAP1, leading to destruction of WAVE regulatory complex and increased lamellipodia formation in HTR-8/SVneo cells, whereas interacted with β-catenin and up-regulated a number of core Wnt/Hippo pathway target genes in JEG-3 cells. This study revealed the differentially functional patterns of LMO2 in different trophoblast subtypes, and suggested LMO2 as a novel target for PE prediction, prevention and treatment in clinical. [Display omitted] •Compared with normal placenta, LMO2 showed decreased expression level in both CTBs and EVTs in preeclampsia placentas.•LMO2 increased cell migration in iEVT derived HTR-8/SVneo cells via targeting to NCKAP1.•LMO2 promoted cell proliferation in CTB derived JEG-3 cells via targeting to beta-Catenin.
Author Chen, Yaxin
Sun, Wei
Chang, Ying
Meng, Yingying
Shen, Yongmei
Yu, Yanhong
Li, Wen
Li, Shanshan
Author_xml – sequence: 1
  givenname: Yaxin
  surname: Chen
  fullname: Chen, Yaxin
  organization: Laboratory of Molecular Genetics, School of Medicine, Nankai University, Tianjin, China
– sequence: 2
  givenname: Yingying
  surname: Meng
  fullname: Meng, Yingying
  organization: Laboratory of Molecular Genetics, School of Medicine, Nankai University, Tianjin, China
– sequence: 3
  givenname: Yanhong
  surname: Yu
  fullname: Yu, Yanhong
  organization: Laboratory of Molecular Genetics, School of Medicine, Nankai University, Tianjin, China
– sequence: 4
  givenname: Wen
  surname: Li
  fullname: Li, Wen
  organization: Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China
– sequence: 5
  givenname: Yongmei
  surname: Shen
  fullname: Shen, Yongmei
  organization: Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China
– sequence: 6
  givenname: Shanshan
  surname: Li
  fullname: Li, Shanshan
  organization: Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China
– sequence: 7
  givenname: Ying
  surname: Chang
  fullname: Chang, Ying
  email: changying4470@sina.com
  organization: Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China
– sequence: 8
  givenname: Wei
  surname: Sun
  fullname: Sun, Wei
  email: sunweibio@nankai.edu.cn
  organization: Laboratory of Molecular Genetics, School of Medicine, Nankai University, Tianjin, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35286869$$D View this record in MEDLINE/PubMed
BookMark eNqNkU9r3DAQxUVJaDZpv0APRcdevB1JtixBLyX0H2zIJYH2JGRpTLRoLVfSpuy3r5dNe-ghFAYeDL83M8y7JGdTmpCQNwzWDJh8v10PQ3ZrDpyvQSwlXpAVAw0NZ9CekRUAyIZr9v2CXJayBWCslfoluRAdV1JJvSI_Nje3nM7RHgr1YRwx41SDjTSniIWGidac5oc0RFsqLfuhHualbydPwyKlJBdsRU9_hfpA54zoot3NJdhX5Hy0seDrJ70i958_3V1_bTa3X75df9w0Tihdm1603umx81pq5YRgA1pocfDoLbOiExZAOwFWO5C97LT2vVK-tUp0Qz8KcUXenebOOf3cY6lmF4rDGO2EaV8Ml61SXcc79h-o0Jz3y8IFffuE7ocdejPnsLP5YP58bgH4CXA5lZJx_IswMMd4zNYc4zHHeAyIpY63qn9MLlRbQ5pqtiE-b_1wsuLyy8eA2RQXcHLoQ0ZXjU_hOftvafiqoQ
CitedBy_id crossref_primary_10_1093_biolre_ioad027
Cites_doi 10.1038/cdd.2015.7
10.1593/neo.09418
10.18632/oncotarget.13434
10.12659/MSMBR.924421
10.1038/nature00859
10.1080/19336918.2015.1098800
10.1089/omi.2011.0118
10.1016/j.mce.2019.110699
10.1038/srep36050
10.1038/nature09623
10.1161/HYPERTENSIONAHA.111.00250
10.1038/s41586-018-0753-3
10.1038/s41586-018-0698-6
10.1038/nature10897
10.1038/sj.onc.1205285
10.1016/j.yexcr.2019.111718
10.1002/path.2109
10.1098/rsob.150062
ContentType Journal Article
Copyright 2022 Elsevier Inc.
Copyright © 2022 Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2022 Elsevier Inc.
– notice: Copyright © 2022 Elsevier Inc. All rights reserved.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
DOI 10.1016/j.bbrc.2022.03.033
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
AGRICOLA
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
Biology
EISSN 1090-2104
EndPage 50
ExternalDocumentID 35286869
10_1016_j_bbrc_2022_03_033
S0006291X22003588
Genre Journal Article
GroupedDBID ---
--K
--M
-~X
.~1
0R~
1B1
1RT
1~.
1~5
23N
4.4
457
4G.
53G
5GY
5VS
6J9
7-5
71M
8P~
9JM
AABNK
AACTN
AAEDT
AAEDW
AAHBH
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AATTM
AAXKI
AAXUO
ABFNM
ABFRF
ABGSF
ABJNI
ABMAC
ABUDA
ACDAQ
ACGFO
ACGFS
ACNCT
ACRLP
ADBBV
ADEZE
ADUVX
AEBSH
AEFWE
AEHWI
AEIPS
AEKER
AENEX
AFFNX
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIKHN
AITUG
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
AXJTR
BKOJK
BLXMC
BNPGV
CS3
D0L
DM4
EBS
EFBJH
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
IHE
J1W
K-O
KOM
L7B
LG5
LX2
M41
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
RNS
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SPCBC
SSH
SSU
SSZ
T5K
TWZ
WH7
XPP
XSW
ZMT
~02
~G-
.55
.GJ
.HR
1CY
3O-
9M8
AAQXK
AAYJJ
AAYWO
AAYXX
ABDPE
ABEFU
ABWVN
ABXDB
ACKIV
ACRPL
ACVFH
ADCNI
ADFGL
ADIYS
ADMUD
ADNMO
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRDE
AGRNS
AHHHB
AIGII
AIIUN
AKBMS
AKYEP
APXCP
ASPBG
AVWKF
AZFZN
CAG
CITATION
COF
EJD
FEDTE
FGOYB
G-2
HLW
HVGLF
HZ~
MVM
OHT
R2-
RIG
SBG
SEW
UQL
WUQ
X7M
Y6R
ZGI
ZKB
~KM
AFKWA
AJOXV
AMFUW
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
ID FETCH-LOGICAL-c389t-734dc9f5d9698c331bea04ebdeda1a353a009c30a9c0676599d788d4a835b7f33
IEDL.DBID .~1
ISSN 0006-291X
1090-2104
IngestDate Fri Jul 11 16:11:56 EDT 2025
Fri Jul 11 15:50:46 EDT 2025
Wed Feb 19 02:26:27 EST 2025
Thu Apr 24 23:02:45 EDT 2025
Tue Jul 01 01:44:25 EDT 2025
Sun Apr 06 06:53:02 EDT 2025
IsPeerReviewed true
IsScholarly true
Keywords STB
NCKAP1
EVT
Wnt pathway
LMO2
Trophoblast
iEVT
CTB
eEVT
WAVE2
WAVE complex
Hippo pathway
PE
Preeclampsia
Language English
License Copyright © 2022 Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c389t-734dc9f5d9698c331bea04ebdeda1a353a009c30a9c0676599d788d4a835b7f33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 35286869
PQID 2639227009
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_2648855251
proquest_miscellaneous_2639227009
pubmed_primary_35286869
crossref_primary_10_1016_j_bbrc_2022_03_033
crossref_citationtrail_10_1016_j_bbrc_2022_03_033
elsevier_sciencedirect_doi_10_1016_j_bbrc_2022_03_033
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-05-14
PublicationDateYYYYMMDD 2022-05-14
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-14
  day: 14
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Biochemical and biophysical research communications
PublicationTitleAlternate Biochem Biophys Res Commun
PublicationYear 2022
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Ma, Guan, Beh (bib7) 2007; 211
Yamada, Pannell, Forster (bib12) 2002; 21
Yu, Wang, Han (bib14) 2012; 16
Nakata, Ohuchida, Nagai (bib6) 2009; 11
Wang, Chen, Chang (bib16) 2020; 26
Jiang, Li, Zhang (bib18) 2020; 22
Kohan-Ghadr, Kadam, Jain (bib20) 2016; 10
Liu, Huang, Wang (bib9) 2016; 6
Eden, Rohatgi, Podtelejnikov (bib17) 2002; 418
Chaiworapongsa, Chaemsaithong, Yeo (bib2) 2014; 10
Chambers, Rabbitts (bib5) 2015; 5
Staff, Benton, von Dadelszen (bib1) 2013; 61
Cui, Wang, Dong (bib4) 2012; 484
Sato (bib19) 2020; 503
Vento-Tormo, Efremova, Botting (bib13) 2018; 563
Liu, Wu, Zhu (bib11) 2017; 23
Kim, Kim, Hitomi (bib8) 2015; 22
Li, Chiu, Yeung (bib21) 2020; 388
Liu, Wang, Huang (bib10) 2017; 8
Turco, Gardner, Kay (bib3) 2018; 564
Chen, Borek, Padrick (bib15) 2010; 468
Staff (10.1016/j.bbrc.2022.03.033_bib1) 2013; 61
Turco (10.1016/j.bbrc.2022.03.033_bib3) 2018; 564
Yu (10.1016/j.bbrc.2022.03.033_bib14) 2012; 16
Jiang (10.1016/j.bbrc.2022.03.033_bib18) 2020; 22
Ma (10.1016/j.bbrc.2022.03.033_bib7) 2007; 211
Wang (10.1016/j.bbrc.2022.03.033_bib16) 2020; 26
Eden (10.1016/j.bbrc.2022.03.033_bib17) 2002; 418
Chen (10.1016/j.bbrc.2022.03.033_bib15) 2010; 468
Chaiworapongsa (10.1016/j.bbrc.2022.03.033_bib2) 2014; 10
Chambers (10.1016/j.bbrc.2022.03.033_bib5) 2015; 5
Sato (10.1016/j.bbrc.2022.03.033_bib19) 2020; 503
Yamada (10.1016/j.bbrc.2022.03.033_bib12) 2002; 21
Li (10.1016/j.bbrc.2022.03.033_bib21) 2020; 388
Nakata (10.1016/j.bbrc.2022.03.033_bib6) 2009; 11
Kohan-Ghadr (10.1016/j.bbrc.2022.03.033_bib20) 2016; 10
Vento-Tormo (10.1016/j.bbrc.2022.03.033_bib13) 2018; 563
Cui (10.1016/j.bbrc.2022.03.033_bib4) 2012; 484
Liu (10.1016/j.bbrc.2022.03.033_bib11) 2017; 23
Kim (10.1016/j.bbrc.2022.03.033_bib8) 2015; 22
Liu (10.1016/j.bbrc.2022.03.033_bib9) 2016; 6
Liu (10.1016/j.bbrc.2022.03.033_bib10) 2017; 8
References_xml – volume: 8
  start-page: 9513
  year: 2017
  end-page: 9524
  ident: bib10
  article-title: LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling
  publication-title: Oncotarget
– volume: 418
  start-page: 790
  year: 2002
  end-page: 793
  ident: bib17
  article-title: Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
  publication-title: Nature
– volume: 468
  start-page: 533
  year: 2010
  end-page: 538
  ident: bib15
  article-title: Structure and control of the actin regulatory WAVE complex
  publication-title: Nature
– volume: 564
  start-page: 263
  year: 2018
  end-page: 267
  ident: bib3
  article-title: Trophoblast organoids as a model for maternal-fetal interactions during human placentation
  publication-title: Nature
– volume: 6
  start-page: 36050
  year: 2016
  ident: bib9
  article-title: LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer
  publication-title: Sci. Rep.
– volume: 211
  start-page: 278
  year: 2007
  end-page: 285
  ident: bib7
  article-title: The significance of LMO2 expression in the progression of prostate cancer
  publication-title: J. Pathol.
– volume: 26
  year: 2020
  ident: bib16
  article-title: Biochemical feature of LMO2 interactome and LMO2 function prospect
  publication-title: Medical science monitor basic research
– volume: 10
  start-page: 466
  year: 2014
  end-page: 480
  ident: bib2
  article-title: Pre-eclampsia part 1: current understanding of its pathophysiology, Nature reviews
  publication-title: Nephrology
– volume: 16
  start-page: 284
  year: 2012
  end-page: 287
  ident: bib14
  article-title: clusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS A J. Integr. Biol.
– volume: 21
  start-page: 1309
  year: 2002
  end-page: 1315
  ident: bib12
  article-title: The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target
  publication-title: Oncogene
– volume: 563
  start-page: 347
  year: 2018
  end-page: 353
  ident: bib13
  article-title: Single-cell reconstruction of the early maternal-fetal interface in humans
  publication-title: Nature
– volume: 22
  start-page: 4101
  year: 2020
  end-page: 4106
  ident: bib18
  article-title: YAP-mediated crosstalk between the Wnt and Hippo signaling pathways (Review)
  publication-title: Mol. Med. Rep.
– volume: 10
  start-page: 126
  year: 2016
  end-page: 135
  ident: bib20
  article-title: Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta
  publication-title: Cell Adhes. Migrat.
– volume: 23
  start-page: 695
  year: 2017
  end-page: 703
  ident: bib11
  article-title: LMO2 enhances lamellipodia/filopodia formation in basal-type breast cancer cells by mediating ARP3-profilin1 interaction
  publication-title: Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.
– volume: 22
  start-page: 1517
  year: 2015
  end-page: 1525
  ident: bib8
  article-title: The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells
  publication-title: Cell Death Differ.
– volume: 5
  start-page: 150062
  year: 2015
  ident: bib5
  article-title: LMO2 at 25 years: a paradigm of chromosomal translocation proteins
  publication-title: Open biology
– volume: 388
  start-page: 111718
  year: 2020
  ident: bib21
  article-title: Regulation of human trophoblast surrogate Jeg-3 spheroids implantation potential by Wnt/β-catenin pathway and lin28a/let-7a axis
  publication-title: Exp. Cell Res.
– volume: 503
  start-page: 110699
  year: 2020
  ident: bib19
  article-title: Endovascular trophoblast and spiral artery remodeling
  publication-title: Mol. Cell. Endocrinol.
– volume: 484
  start-page: 246
  year: 2012
  end-page: 250
  ident: bib4
  article-title: Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy
  publication-title: Nature
– volume: 11
  start-page: 712
  year: 2009
  end-page: 719
  ident: bib6
  article-title: LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer
  publication-title: Neoplasia
– volume: 61
  start-page: 932
  year: 2013
  end-page: 942
  ident: bib1
  article-title: Redefining preeclampsia using placenta-derived biomarkers
  publication-title: Hypertension
– volume: 22
  start-page: 1517
  year: 2015
  ident: 10.1016/j.bbrc.2022.03.033_bib8
  article-title: The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2015.7
– volume: 11
  start-page: 712
  year: 2009
  ident: 10.1016/j.bbrc.2022.03.033_bib6
  article-title: LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer
  publication-title: Neoplasia
  doi: 10.1593/neo.09418
– volume: 8
  start-page: 9513
  year: 2017
  ident: 10.1016/j.bbrc.2022.03.033_bib10
  article-title: LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.13434
– volume: 26
  year: 2020
  ident: 10.1016/j.bbrc.2022.03.033_bib16
  article-title: Biochemical feature of LMO2 interactome and LMO2 function prospect
  publication-title: Medical science monitor basic research
  doi: 10.12659/MSMBR.924421
– volume: 418
  start-page: 790
  year: 2002
  ident: 10.1016/j.bbrc.2022.03.033_bib17
  article-title: Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
  publication-title: Nature
  doi: 10.1038/nature00859
– volume: 10
  start-page: 126
  year: 2016
  ident: 10.1016/j.bbrc.2022.03.033_bib20
  article-title: Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta
  publication-title: Cell Adhes. Migrat.
  doi: 10.1080/19336918.2015.1098800
– volume: 16
  start-page: 284
  year: 2012
  ident: 10.1016/j.bbrc.2022.03.033_bib14
  article-title: clusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS A J. Integr. Biol.
  doi: 10.1089/omi.2011.0118
– volume: 10
  start-page: 466
  year: 2014
  ident: 10.1016/j.bbrc.2022.03.033_bib2
  article-title: Pre-eclampsia part 1: current understanding of its pathophysiology, Nature reviews
  publication-title: Nephrology
– volume: 503
  start-page: 110699
  year: 2020
  ident: 10.1016/j.bbrc.2022.03.033_bib19
  article-title: Endovascular trophoblast and spiral artery remodeling
  publication-title: Mol. Cell. Endocrinol.
  doi: 10.1016/j.mce.2019.110699
– volume: 6
  start-page: 36050
  year: 2016
  ident: 10.1016/j.bbrc.2022.03.033_bib9
  article-title: LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer
  publication-title: Sci. Rep.
  doi: 10.1038/srep36050
– volume: 468
  start-page: 533
  year: 2010
  ident: 10.1016/j.bbrc.2022.03.033_bib15
  article-title: Structure and control of the actin regulatory WAVE complex
  publication-title: Nature
  doi: 10.1038/nature09623
– volume: 61
  start-page: 932
  year: 2013
  ident: 10.1016/j.bbrc.2022.03.033_bib1
  article-title: Redefining preeclampsia using placenta-derived biomarkers
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.00250
– volume: 564
  start-page: 263
  year: 2018
  ident: 10.1016/j.bbrc.2022.03.033_bib3
  article-title: Trophoblast organoids as a model for maternal-fetal interactions during human placentation
  publication-title: Nature
  doi: 10.1038/s41586-018-0753-3
– volume: 563
  start-page: 347
  year: 2018
  ident: 10.1016/j.bbrc.2022.03.033_bib13
  article-title: Single-cell reconstruction of the early maternal-fetal interface in humans
  publication-title: Nature
  doi: 10.1038/s41586-018-0698-6
– volume: 484
  start-page: 246
  year: 2012
  ident: 10.1016/j.bbrc.2022.03.033_bib4
  article-title: Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy
  publication-title: Nature
  doi: 10.1038/nature10897
– volume: 21
  start-page: 1309
  year: 2002
  ident: 10.1016/j.bbrc.2022.03.033_bib12
  article-title: The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205285
– volume: 388
  start-page: 111718
  year: 2020
  ident: 10.1016/j.bbrc.2022.03.033_bib21
  article-title: Regulation of human trophoblast surrogate Jeg-3 spheroids implantation potential by Wnt/β-catenin pathway and lin28a/let-7a axis
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2019.111718
– volume: 211
  start-page: 278
  year: 2007
  ident: 10.1016/j.bbrc.2022.03.033_bib7
  article-title: The significance of LMO2 expression in the progression of prostate cancer
  publication-title: J. Pathol.
  doi: 10.1002/path.2109
– volume: 23
  start-page: 695
  year: 2017
  ident: 10.1016/j.bbrc.2022.03.033_bib11
  article-title: LMO2 enhances lamellipodia/filopodia formation in basal-type breast cancer cells by mediating ARP3-profilin1 interaction
  publication-title: Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.
– volume: 22
  start-page: 4101
  year: 2020
  ident: 10.1016/j.bbrc.2022.03.033_bib18
  article-title: YAP-mediated crosstalk between the Wnt and Hippo signaling pathways (Review)
  publication-title: Mol. Med. Rep.
– volume: 5
  start-page: 150062
  year: 2015
  ident: 10.1016/j.bbrc.2022.03.033_bib5
  article-title: LMO2 at 25 years: a paradigm of chromosomal translocation proteins
  publication-title: Open biology
  doi: 10.1098/rsob.150062
SSID ssj0011469
Score 2.40022
Snippet Preeclampsia (PE) is a common obstetric disease caused by placenta development abnormality, typically characterized as inadequate trophoblast invasion and...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 43
SubjectTerms Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Cell Line, Tumor
Cell Movement
Female
Hippo pathway
Humans
LIM Domain Proteins - genetics
LIM Domain Proteins - metabolism
LMO2
Placenta - metabolism
Placentation
pre-eclampsia
Pre-Eclampsia - metabolism
prediction
Preeclampsia
Pregnancy
Proto-Oncogene Proteins - metabolism
pseudopodia
Trophoblast
Trophoblasts - metabolism
WAVE complex
Wnt pathway
Title LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia
URI https://dx.doi.org/10.1016/j.bbrc.2022.03.033
https://www.ncbi.nlm.nih.gov/pubmed/35286869
https://www.proquest.com/docview/2639227009
https://www.proquest.com/docview/2648855251
Volume 604
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9RAEG6WFdGL6K6P8bG0IF4kbtKPzPRxHFzGx64XF8ZTqH4EI2MmTDKHvfjbrUo6Ax52DkIgDzrQdFVXfVVdD8beKAk-hBQSY8hbBbjTwfiQaF8G4TVkoqR858urfHmtPq_06ogtxlwYCquMsn-Q6b20jl_O42qeN1VFOb5pLky2En1Rzxkl_Co1JS5__2cf5kFJtxEC5wmNjokzQ4yXtVsqYyhEX-hUytuU023gs1dCFw_Zg4ge-XyY4CN2FOoTdjqv0XL-fcPf8j6es3eUn7C7H8ane4uxq9sp-_H18pvgzRpuWj42R8FNvuYUZtjyqubddtP83FhE1R1vd5Z8tC2H2vMKb5GYwXNy4PJmG4JDnmraCh6z64uP3xfLJLZXSByilC6ZSuWdKbU3uZk5KTMbIFXB-uAhA6klIP5yMgXjUKXl2hiP9rJXgKDNTkspn7DjelOHZ4xbcEYgmHE-LxVIOysVmpIhgFFowEg3Ydm4roWLtcepBca6GIPMfhVEi4JoUaQSLzlh7_b_NEPljYOj9Uiu4h_-KVA1HPzv9UjbAilBpyVQh82uLQRiN0HH8ubQGJR_WiNGnLCnA2Ps50plc_JZbp7_58xesPv0RpEKmXrJjrvtLrxCANTZs57Dz9id-acvy6u_cQ4EzQ
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKESoXBC2P5WkkxAWFJn6k8bGsqBbYLZdWWk6WXxFBSzbaZA-98NuZSZyVOHQPSJESJY5kecYz34znQcg7wY0PITWJUuitMrDTjfIhkb4MzEuTsRLznReX-exafF3K5QGZjrkwGFYZZf8g03tpHd-cxtU8baoKc3zTnKlsyfqinkVxh9wVsH2xjcHHP7s4D8y6jRg4T3B4zJwZgrys3WAdQ8b6Sqec36adbkOfvRa6eEgeRPhIz4cZPiIHoT4mJ-c1mM6_b-h72gd09p7yY3Lv0_h0NB3bup2QH_PFd0ablblp6dgdBXb5imKcYUurmnabdfNzbQFWd7TdWnTSttTUnlZwi9QMnqIHlzabEBwwVdNW5jG5vvh8NZ0lsb9C4gCmdMkZF96pUnqVq8JxntlgUhGsD95khktuAIA5nhrlQKflUikPBrMXBlCbPSs5f0IO63UdnhFqjVMM0IzzeSkMt0UpwJYMwSgBFgx3E5KN66pdLD6OPTBWeowy-6WRFhppoVMOF5-QD7t_mqH0xt7RciSX_oeBNOiGvf-9HWmrgRJ4XGLqsN62mgF4Y3gur_aNAQEoJYDECXk6MMZurlg3Jy9y9fw_Z_aGHM2uFnM9_3L57QW5j18wbCETL8lht9mGV4CGOvu65_a_UlsGWw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=LMO2+plays+differential+roles+in+trophoblast+subtypes+and+is+associated+with+preeclampsia&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.au=Chen%2C+Yaxin&rft.au=Meng%2C+Yingying&rft.au=Yu%2C+Yanhong&rft.au=Li%2C+Wen&rft.date=2022-05-14&rft.eissn=1090-2104&rft.volume=604&rft.spage=43&rft_id=info:doi/10.1016%2Fj.bbrc.2022.03.033&rft_id=info%3Apmid%2F35286869&rft.externalDocID=35286869
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-291X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-291X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-291X&client=summon