Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis

• Published in: Journal of cell science Vol. 136; no. 3
• Main Authors: Foo, Sherman, Cazenave-Gassiot, Amaury, Wenk, Markus R., Oliferenko, Snezhana
• Format: Journal Article
• Language: English
• Published: England 01.02.2023
• Subjects: Cell Nucleus Division; Diglycerides - metabolism; Glycerophospholipids - metabolism; Mitosis; Nuclear Envelope - metabolism; Schizosaccharomyces - metabolism; Closed mitosis; Nuclear envelope; Diacylglycerol

Nuclear envelope (NE) expansion must be controlled to maintain nuclear shape and function. The nuclear membrane expands massively during closed mitosis, enabling chromosome segregation within an intact NE. Phosphatidic acid (PA) and diacylglycerol (DG) can both serve as biosynthetic precursors for m...