Heparin-Releasable Endothelial Cell-Associated Tissue Factor Pathway Inhibitor (Tfpi) is Increased in the Coronary Circulation After Coronary Spasm in Patients with Coronary Spastic Angina

• Published in: Thrombosis research Vol. 89; no. 3; pp. 137 - 146
• Main Authors: Nishiyama, K, Ogawa, H, Yasue, H, Soejima, H, Misumi, K, Kugiyama, K, Tsuji, I, Kumeda, K
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01.02.1998; Elsevier Science
• Subjects: Aged; Angina Pectoris - blood; Angina Pectoris - physiopathology; Anticoagulants - administration & dosage; Biological and medical sciences; Cardiology. Vascular system; Coronary Circulation; Coronary heart disease; Coronary spasm; Coronary Vasospasm - blood; Coronary Vasospasm - physiopathology; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Female; Heart; Heparin - administration & dosage; Humans; Lipoproteins - blood; Male; Medical sciences; Middle Aged; Tissue factor pathway inhibitor; Coronary spasm; Tissue factor pathway inhibitor; Human; Endothelial cell; Kunitz inhibitor; Coronary artery; Tissue factor; Cardiovascular disease; Anticoagulant; Angina pectoris; Coronary heart disease; Arterial disease; Vascular disease; Chemotherapy; Treatment; Spasm; Glycosaminoglycan; Heparin

Tissue factor pathway inhibitor (TFPI) is a physiological regulator of the extrinsic coagulation cascade. Coronary spasm can alter endothelial cell properties in the coronary artery with resultant thrombosis. To determine whether coronary spasm affects plasma TFPI level, we measured the heparin-rele...