Effects of high fat diet on lipid accumulation, oxidative stress and autophagy in the liver of Chinese softshell turtle (Pelodiscus sinensis)

• Published in: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Vol. 240; p. 110331
• Main Authors: Zhong, Yiwen, Pan, Yaxiong, Liu, Li, Li, Honghui, Li, Yulong, Jiang, Jian, Xiang, Jing, Zhang, Jianshe, Chu, Wuying
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.2020
• Subjects: adenosine monophosphate; alanine transaminase; Animals; antioxidant activity; aspartate transaminase; Autophagic Cell Death - drug effects; Autophagy; blood serum; catalase; cholesterol; Dietary Fats - adverse effects; Dietary Fats - pharmacology; enzyme activity; gene expression; gene expression regulation; glutathione; glutathione peroxidase; glutathione transferase; high density lipoprotein; High fat diet; Lipid accumulation; lipid content; Lipid Metabolism - drug effects; liver; Liver - metabolism; Liver - pathology; Liver injury; low density lipoprotein; malondialdehyde; mammals; messenger RNA; Oxidative stress; Oxidative Stress - drug effects; oxidative toxicity; Pelodiscus sinensis; protein kinases; rapamycin; reactive oxygen species; superoxide dismutase; triacylglycerols; turtles; Turtles - metabolism; Oxidative stress; Pelodiscus sinensis; Lipid accumulation; Autophagy; High fat diet; Liver injury

The present study was performed to determine the effect of high fat diet in lipid accumulation, oxidative stress and autophagy, and to explore the underlying molecular mechanism of high fat diet induced hepatic oxidative damage in Chinese softshell turtle. To this end, the control group were fed a n...