Multivalent acetylated-sialic acid as recognition elements for the electrochemical sensing of viral antigens

• Published in: Biosensors & bioelectronics Vol. 268; p. 116883
• Main Authors: Zhang, Zhen, Ji, Haijie, Zhuang, Xiwei, Xu, Yuning, Liu, Jianlei, Zeng, Chijia, Ding, Wen, Cui, Feiyun, Zhu, Sanyong
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.01.2025
• Subjects: Acetylated-sialic acid (SA); Acetylation; antigen detection; Antigens, Viral - analysis; Antigens, Viral - immunology; biocompatibility; Biosensing Techniques - methods; biosensors; Cluster glucoside effect; COVID-19 - diagnosis; COVID-19 - virology; Dielectric Spectroscopy; Electrochemical biosensors; Electrochemical Techniques - methods; electrochemistry; glycosides; Humans; Instant screening test (IST); molecular imprinting; N-Acetylneuraminic Acid - analysis; N-Acetylneuraminic Acid - chemistry; oligonucleotides; polysaccharides; SARS-CoV-2 - immunology; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - analysis; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Viral antigen; viral antigens; Cluster glucoside effect; Instant screening test (IST); Electrochemical biosensors; Viral antigen; Acetylated-sialic acid (SA)

Electrochemical biosensors hold great promise for the rapid screening of viral infectious diseases. However, the recognition elements of these biosensors are typically limited to antibodies, aptamers, and molecularly imprinted polymers. In this study, acetylated sialic acids were explored as recogni...