CD47-mediated immune evasion in early-stage lung cancer progression

• Published in: Biochemical and biophysical research communications Vol. 720; p. 150066
• Main Authors: Chuang, Cheng-Hao, Zhen, Yen-Yi, Ma, Juei-Yang, Lee, Tai-Huang, Hung, Huei-Yang, Wu, Chun-Chieh, Wang, Pei-Hui, Huang, Ching-Tang, Huang, Ming-Shyan, Hsiao, Michael, Lee, Ying-Ray, Huang, Chi-Ying F., Chang, Yu-Chan, Yang, Chih-Jen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2024
• Subjects: Animals; antigen presentation; blood serum; carcinogenesis; CD47 Antigen - immunology; CD47 Antigen - metabolism; Cell Line, Tumor; cytoplasm; Disease Progression; Extracellular vesicles; Extracellular Vesicles - immunology; Extracellular Vesicles - metabolism; Female; Humans; Immune checkpoint; Immune Evasion; ligands; lung neoplasms; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Macrophage; macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; neoplasm cells; neoplasm progression; Neoplasm Staging; patients; phagocytosis; transmembrane proteins; Tumor Escape; Tumor microenvironment; Tumor Microenvironment - immunology; xenotransplantation; Extracellular vesicles; Immune checkpoint; Immune evasion; Tumor microenvironment; Macrophage

Alveolar and interstitial macrophages play crucial roles in eradicating pathogens and transformed cells in the lungs. The immune checkpoint CD47, found on normal and malignant cells, interacts with the SIRPα ligand on macrophages, inhibiting phagocytosis, antigen presentation, and promoting immune e...