Selenium and Prostate Cancer Prevention: What Next-If Anything?
Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement w...
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| Published in | Cancer prevention research (Philadelphia, Pa.) Vol. 7; no. 8; pp. 781 - 785 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
American Association for Cancer Research
01.08.2014
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| Subjects | |
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| Abstract | Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential. Identification of men most likely to benefit from Se status improvement could have significant public health benefits. |
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| AbstractList | Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential. Identification of men most likely to benefit from Se status improvement could have significant public health benefits. Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential. Identification of men most likely to benefit from Se status improvement could have significant public health benefits. Cancer Prev Res; 7(8); 781–5. ©2014 AACR. |
| Author | CHRISTENSEN, Merrill J |
| Author_xml | – sequence: 1 givenname: Merrill J surname: CHRISTENSEN fullname: CHRISTENSEN, Merrill J organization: Department of Nutrition, Dietetics, and Food Science, and Cancer Research Center, Brigham Young University, Provo, Utah, United States |
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| Cites_doi | 10.1002/1520-670X(2000)13:4<333::AID-JTRA2>3.0.CO;2-P 10.1002/pros.22573 10.1016/S0946-672X(98)80015-1 10.1039/B305455A 10.1093/carcin/bgn007 10.1001/jama.2008.864 10.1093/carcin/bgi077 10.1093/jn/126.1.138 10.1039/an9962100189 10.1016/j.atherosclerosis.2010.01.005 10.1684/bdc.2013.1739 10.1001/archinternmed.2007.74 10.1080/01635581.2011.563029 10.1093/jnci/dju003 10.1046/j.1464-410X.2003.04167.x 10.1093/ajcn/81.4.829 10.1016/j.chroma.2013.10.012 10.1002/ijc.22500 10.1080/10408398.2012.742861 10.1158/1055-9965.EPI-05-0950 10.1158/1940-6207.CAPR-14-0042 10.1126/science.1083516 10.1017/S0007114508922522 10.3945/ajcn.111.033373 10.1007/s00216-012-6294-y 10.1186/1475-2891-10-75 10.3945/jn.111.146498 10.1002/iub.38 10.1093/jnci/djt456 10.1158/1940-6207.CAPR-10-0343 10.1093/jnci/90.16.1219 10.1001/jama.2011.1437 10.1158/1940-6207.CAPR-08-0173 10.1002/biof.5520140115 10.1080/10590501.2013.844757 10.1093/jn/136.5.1311 10.5012/bkcs.2013.34.12.3817 10.1371/journal.pone.0048709 |
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| Keywords | Micronutrient Prevention Urinary system disease Prostate disease Malignant tumor Selenium Male genital diseases Prostate cancer Cancer |
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| References | 24938534 - Cancer Prev Res (Phila). 2014 Aug;7(8):796-804 Irons (2022060816242236500_bib36) 2006; 136 Burk (2022060816242236500_bib27) 2006; 15 Klein (2022060816242236500_bib7) 2011; 306 Geybels (2022060816242236500_bib14) 2014; 106 Hurst (2022060816242236500_bib3) 2012; 96 Quiner (2022060816242236500_bib5) 2011; 141 Institute of Medicine (2022060816242236500_bib23) 2000 Lippman (2022060816242236500_bib40) 2009; 301 Yoshizawa (2022060816242236500_bib13) 1998; 90 Abdulah (2022060816242236500_bib16) 2011; 39 Richie (2022060816242236500_bib19) 2014; 3 Hurst (2022060816242236500_bib20) 2013; 53 Solovyev (2022060816242236500_bib35) 2013; 405 Gu (2022060816242236500_bib30) 1998; 12 Waters (2022060816242236500_bib11) 2005; 26 Garcia-Sevillano (2022060816242236500_bib29) 2013; 1318 Dennert (2022060816242236500_bib2) 2011 Marshall (2022060816242236500_bib8) 2011; 4 Pinto (2022060816242236500_bib15) 2007; 120 Kryukov (2022060816242236500_bib21) 2003; 300 Squires (2022060816242236500_bib22) 2008; 60 Algotar (2022060816242236500_bib9) 2013; 73 Jeong (2022060816242236500_bib32) 2013; 34 Hill (2022060816242236500_bib26) 1996; 126 Laclaustra (2022060816242236500_bib39) 2010; 210 Meplan (2022060816242236500_bib42) 2012; 7 Harrison (2022060816242236500_bib31) 1996; 121 Kristal (2022060816242236500_bib10) 2014; 106 Wang (2022060816242236500_bib38) 2009; 2 Zhang (2022060816242236500_bib18) 2011; 63 Combs (2022060816242236500_bib25) 2011; 10 Xia (2022060816242236500_bib34) 2000; 13 Eisinger (2022060816242236500_bib1) 2013; 100 Rayman (2022060816242236500_bib37) 2008; 100 Vinceti (2022060816242236500_bib4) 2014; 3 Bleys (2022060816242236500_bib12) 2008; 168 Duffield-Lillico (2022060816242236500_bib6) 2003; 91 Xia (2022060816242236500_bib24) 2005; 81 Burk (2022060816242236500_bib28) 2001; 14 Reyes (2022060816242236500_bib33) 2003; 18 Li (2022060816242236500_bib17) 2008; 29 Vinceti (2022060816242236500_bib41) 2013; 31 |
| References_xml | – volume: 13 start-page: 333 year: 2000 ident: 2022060816242236500_bib34 article-title: Distribution of selenium between fractions in erythrocytes, plasma, hair, and fingernails of Chinese women living in selenium-deficient, -adequate, and -excessive areas of China publication-title: J Trace Elem Exp Med doi: 10.1002/1520-670X(2000)13:4<333::AID-JTRA2>3.0.CO;2-P contributor: fullname: Xia – volume: 73 start-page: 328 year: 2013 ident: 2022060816242236500_bib9 article-title: Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer publication-title: Prostate doi: 10.1002/pros.22573 contributor: fullname: Algotar – volume: 12 start-page: 8 year: 1998 ident: 2022060816242236500_bib30 article-title: Distribution of selenium between plasma fractions in guinea pigs and humans with various intakes of dietary selenium publication-title: J Trace Elem Med Biol doi: 10.1016/S0946-672X(98)80015-1 contributor: fullname: Gu – volume: 18 start-page: 1210 year: 2003 ident: 2022060816242236500_bib33 article-title: Quantitative speciation of selenium in human serum by affinity chromatography coupled to post-column isotope dilution analysis ICP-MS publication-title: J Anal At Spectrom doi: 10.1039/B305455A contributor: fullname: Reyes – volume: 29 start-page: 1005 year: 2008 ident: 2022060816242236500_bib17 article-title: Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite publication-title: Carcinogenesis doi: 10.1093/carcin/bgn007 contributor: fullname: Li – volume: 301 start-page: 39 year: 2009 ident: 2022060816242236500_bib40 article-title: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) publication-title: JAMA doi: 10.1001/jama.2008.864 contributor: fullname: Lippman – volume: 26 start-page: 1256 year: 2005 ident: 2022060816242236500_bib11 article-title: Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model publication-title: Carcinogenesis doi: 10.1093/carcin/bgi077 contributor: fullname: Waters – volume: 126 start-page: 138 year: 1996 ident: 2022060816242236500_bib26 article-title: Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects publication-title: J Nutr doi: 10.1093/jn/126.1.138 contributor: fullname: Hill – volume: 121 start-page: 189 year: 1996 ident: 2022060816242236500_bib31 article-title: Distribution of selenium in human blood plasma and serum publication-title: Analyst doi: 10.1039/an9962100189 contributor: fullname: Harrison – volume: 210 start-page: 643 year: 2010 ident: 2022060816242236500_bib39 article-title: Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2010.01.005 contributor: fullname: Laclaustra – volume: 100 start-page: 497 year: 2013 ident: 2022060816242236500_bib1 article-title: Pharmaco and diet based prostate cancer prevention publication-title: Bull Cancer doi: 10.1684/bdc.2013.1739 contributor: fullname: Eisinger – volume: 168 start-page: 404 year: 2008 ident: 2022060816242236500_bib12 article-title: Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults publication-title: Arch Intern Med doi: 10.1001/archinternmed.2007.74 contributor: fullname: Bleys – volume: 63 start-page: 778 year: 2011 ident: 2022060816242236500_bib18 article-title: Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds publication-title: Nutr Cancer doi: 10.1080/01635581.2011.563029 contributor: fullname: Zhang – volume: 106 start-page: dju003 year: 2014 ident: 2022060816242236500_bib14 article-title: Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer publication-title: J Natl Cancer Inst doi: 10.1093/jnci/dju003 contributor: fullname: Geybels – volume: 91 start-page: 608 year: 2003 ident: 2022060816242236500_bib6 article-title: Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial publication-title: BJU Int doi: 10.1046/j.1464-410X.2003.04167.x contributor: fullname: Duffield-Lillico – volume: 81 start-page: 829 year: 2005 ident: 2022060816242236500_bib24 article-title: Effectiveness of selenium supplements in a low-selenium area of China publication-title: Am J Clin Nutr doi: 10.1093/ajcn/81.4.829 contributor: fullname: Xia – volume: 1318 start-page: 171 year: 2013 ident: 2022060816242236500_bib29 article-title: Development of a new column switching method for simultaneous speciation of selenometabolites and selenoproteins in human serum publication-title: J Chromatogr A doi: 10.1016/j.chroma.2013.10.012 contributor: fullname: Garcia-Sevillano – volume: 120 start-page: 1410 year: 2007 ident: 2022060816242236500_bib15 article-title: Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells publication-title: Int J Cancer doi: 10.1002/ijc.22500 contributor: fullname: Pinto – volume: 53 start-page: 1077 year: 2013 ident: 2022060816242236500_bib20 article-title: EURRECA-Estimating selenium requirements for deriving dietary reference values publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408398.2012.742861 contributor: fullname: Hurst – volume: 15 start-page: 804 year: 2006 ident: 2022060816242236500_bib27 article-title: Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-05-0950 contributor: fullname: Burk – volume: 3 start-page: 796 year: 2014 ident: 2022060816242236500_bib19 article-title: Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial publication-title: Cancer Prev Res doi: 10.1158/1940-6207.CAPR-14-0042 contributor: fullname: Richie – start-page: 284 year: 2000 ident: 2022060816242236500_bib23 article-title: Selenium. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids contributor: fullname: Institute of Medicine – volume: 300 start-page: 1439 year: 2003 ident: 2022060816242236500_bib21 article-title: Characterization of mammalian selenoproteomes publication-title: Science doi: 10.1126/science.1083516 contributor: fullname: Kryukov – volume: 100 start-page: 238 year: 2008 ident: 2022060816242236500_bib37 article-title: Food-chain selenium and human health: spotlight on speciation publication-title: Br J Nutr doi: 10.1017/S0007114508922522 contributor: fullname: Rayman – volume: 96 start-page: 111 year: 2012 ident: 2022060816242236500_bib3 article-title: Selenium and prostate cancer: systematic review and meta-analysis publication-title: Am J Clin Nutr doi: 10.3945/ajcn.111.033373 contributor: fullname: Hurst – volume: 405 start-page: 1875 year: 2013 ident: 2022060816242236500_bib35 article-title: Selenium speciation in paired serum and cerebrospinal fluid samples publication-title: Anal Bioanal Chem doi: 10.1007/s00216-012-6294-y contributor: fullname: Solovyev – volume: 10 start-page: 75 year: 2011 ident: 2022060816242236500_bib25 article-title: Determinants of selenium status in healthy adults publication-title: Nutr J doi: 10.1186/1475-2891-10-75 contributor: fullname: Combs – volume: 141 start-page: 2159 year: 2011 ident: 2022060816242236500_bib5 article-title: Soy content of basal diets determines the effects of supplemental selenium in male mice publication-title: J Nutr doi: 10.3945/jn.111.146498 contributor: fullname: Quiner – volume: 60 start-page: 232 year: 2008 ident: 2022060816242236500_bib22 article-title: Eukaryotic selenoprotein synthesis: mechanistic insight incorporating new factors and new functions for old factors publication-title: IUBMB Life doi: 10.1002/iub.38 contributor: fullname: Squires – start-page: CD005195 year: 2011 ident: 2022060816242236500_bib2 article-title: Selenium for preventing cancer publication-title: Cochrane Database Syst Rev contributor: fullname: Dennert – volume: 106 start-page: djt456 year: 2014 ident: 2022060816242236500_bib10 article-title: Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djt456 contributor: fullname: Kristal – volume: 4 start-page: 1761 year: 2011 ident: 2022060816242236500_bib8 article-title: Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917 publication-title: Cancer Prev Res doi: 10.1158/1940-6207.CAPR-10-0343 contributor: fullname: Marshall – volume: 90 start-page: 1219 year: 1998 ident: 2022060816242236500_bib13 article-title: Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.16.1219 contributor: fullname: Yoshizawa – volume: 306 start-page: 1549 year: 2011 ident: 2022060816242236500_bib7 article-title: Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) publication-title: JAMA doi: 10.1001/jama.2011.1437 contributor: fullname: Klein – volume: 2 start-page: 484 year: 2009 ident: 2022060816242236500_bib38 article-title: Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit publication-title: Cancer Prev Res doi: 10.1158/1940-6207.CAPR-08-0173 contributor: fullname: Wang – volume: 14 start-page: 107 year: 2001 ident: 2022060816242236500_bib28 article-title: Plasma selenium in specific and non-specific forms publication-title: Biofactors doi: 10.1002/biof.5520140115 contributor: fullname: Burk – volume: 31 start-page: 305 year: 2013 ident: 2022060816242236500_bib41 article-title: Friend or foe? The current epidemiolgic evidence on selenium and human cancer risk publication-title: J Environ Sci Heal C doi: 10.1080/10590501.2013.844757 contributor: fullname: Vinceti – volume: 39 start-page: 301 year: 2011 ident: 2022060816242236500_bib16 article-title: Molecular targets of selenium in prostate cancer prevention (Review) publication-title: Int J Oncol contributor: fullname: Abdulah – volume: 136 start-page: 1311 year: 2006 ident: 2022060816242236500_bib36 article-title: Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression publication-title: J Nutr doi: 10.1093/jn/136.5.1311 contributor: fullname: Irons – volume: 3 start-page: CD005195 year: 2014 ident: 2022060816242236500_bib4 article-title: Selenium for preventing cancer publication-title: Cochrane Database Syst Rev contributor: fullname: Vinceti – volume: 34 start-page: 3817 year: 2013 ident: 2022060816242236500_bib32 article-title: Quantitative speciation of selenium in human blood serum and urine with AE- RP- and AF-HPLC-ICP/MS publication-title: Bull Korean Chem Soc doi: 10.5012/bkcs.2013.34.12.3817 contributor: fullname: Jeong – volume: 7 start-page: e48709 year: 2012 ident: 2022060816242236500_bib42 article-title: Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer publication-title: PLoS ONE doi: 10.1371/journal.pone.0048709 contributor: fullname: Meplan |
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| Title | Selenium and Prostate Cancer Prevention: What Next-If Anything? |
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