Selenium and Prostate Cancer Prevention: What Next-If Anything?

• Published in: Cancer prevention research (Philadelphia, Pa.) Vol. 7; no. 8; pp. 781 - 785
• Main Author: CHRISTENSEN, Merrill J
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.08.2014
• Subjects: Biological and medical sciences; Biomarkers - metabolism; Humans; Male; Medical sciences; Miscellaneous; Nephrology. Urinary tract diseases; Oxidative Stress - drug effects; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Selenium - administration & dosage; Selenomethionine - administration & dosage; Tumors of the urinary system; Urinary tract. Prostate gland; Micronutrient; Prevention; Urinary system disease; Prostate disease; Malignant tumor; Selenium; Male genital diseases; Prostate cancer; Cancer
• ISSN: 1940-6207; 1940-6215
• DOI: 10.1158/1940-6207.CAPR-14-0197

Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential. Identification of men most likely to benefit from Se status improvement could have significant public health benefits.