The fate of collagen during experimental liver lesion with carbon tetrachloride in the presence and absence of colchicine

Collagen was examined during experimental lesion of the liver with carbon tetrachloride in the presence and absence of colchicine. The experimental animals were Wistar rats, young, of both sexes. The fate of collagen was determined by quantitative assessment of the soluble fraction in salts (NSC), o...

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Published inExperimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 44; no. 1; p. 15
Main Authors Wardas, M, Drózdz, M, Wichary, M, Radwańska-Wala, B
Format Journal Article
LanguageEnglish
Published Germany 01.03.1992
Subjects
Animals
Carbon Tetrachloride - antagonists & inhibitors
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - metabolism
Chemical and Drug Induced Liver Injury - prevention & control
Colchicine - pharmacology
Collagen - metabolism
Female
Male
Rats
Rats, Wistar
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Summary:Collagen was examined during experimental lesion of the liver with carbon tetrachloride in the presence and absence of colchicine. The experimental animals were Wistar rats, young, of both sexes. The fate of collagen was determined by quantitative assessment of the soluble fraction in salts (NSC), of the soluble fraction in acids (ASC) and of the insoluble fraction (ISC). The results that were obtained indicate protective action of colchicine during the experimental lesion of the liver with CCl4.
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(11)80131-4