Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients

• Published in: Biological psychiatry (1969) Vol. 43; no. 10; pp. 767 - 773
• Main Authors: Rocca, Paola, Beoni, Anna Maria, Eva, Carola, Ferrero, Patrizia, Zanalda, Enrico, Ravizza, Luigi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.05.1998; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Anti-Anxiety Agents - therapeutic use; Anxiety Disorders - blood; Anxiety Disorders - drug therapy; Anxiety Disorders - genetics; Anxiety disorders. Neuroses; Benzodiazepines; Biological and medical sciences; Female; Follow-Up Studies; generalized anxiety disorder; Humans; Lymphocytes - metabolism; Male; Medical sciences; Middle Aged; Miscellaneous; Nordazepam - analogs & derivatives; Nordazepam - therapeutic use; Peripheral benzodiazepine receptor; peripheral benzodiazepine receptor messenger RNA; Polymerase Chain Reaction; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, GABA-A - drug effects; Receptors, GABA-A - genetics; RNA, Messenger - blood; Peripheral benzodiazepine receptor; benzodiazepines; generalized anxiety disorder; peripheral benzodiazepine receptor messenger RNA; Human; Messenger RNA; Generalized anxiety disorder; Anxiety disorder; Biological marker; Lymphocyte

Background: The aim of this study was to assess whether the decrease of peripheral benzodiazepine receptor (pBR) number in peripheral blood mononuclear cells (PBMC), previously observed in patients with generalized anxiety disorder, is paralleled by changes in the relative content of messenger RNA (...