Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 90; pp. 35 - 44
• Main Authors: Liu, Yue-tao, Jia, Hong-mei, Chang, Xing, Cheng, Wei-hua, Zhao, Xin, Ding, Gang, Zhang, Hong-wu, Cai, Da-yong, Zou, Zhong-Mei
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.03.2014
• Subjects: Administration, Oral; Animals; Biomarkers - analysis; Cardiotonic Agents - administration & dosage; Cardiotonic Agents - pharmacology; Chromatography, High Pressure Liquid - methods; Disease Models, Animal; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacology; Isoproterenol - toxicity; Male; Mass Spectrometry - methods; Medicine, Chinese Traditional - methods; Metabolic pathways; Metabolomics - methods; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - prevention & control; Pharmacological action; Plasma metabonomics; Rats; Rats, Wistar; Xin-Ke-Shu; Myocardial infarction; Metabolic pathways; Pharmacological action; Xin-Ke-Shu; Plasma metabonomics

Two genres of metabolic biomarkers, pathological biomarkers and pharmaco biomarkers were characterized to illustrate the underlying mechanism of Xin-Ke-Shu against isoproterenol (ISO)-induced myocardial infarction. •We study the protection of XKS on ISO-induced MI rats using a metabonomics.•Two genr...