Rapid recovery from capsaicin desensitization during recurrent stimulation

• Published in: Pain (Amsterdam) Vol. 68; no. 2; pp. 245 - 253
• Main Author: Green, Barry G.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.1996; Elsevier
• Subjects: Administration, Oral; Adult; Alkaloids; Analysis of Variance; Benzodioxoles; Biological and medical sciences; Capsaicin; Capsaicin - pharmacology; Citric Acid - pharmacology; Depression, Chemical; Desensitization; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Guaiacol - analogs & derivatives; Guaiacol - pharmacology; Human; Humans; Irritants - pharmacology; Logistic Models; Male; Oral; Piperidines - pharmacology; Piperine; Polyunsaturated Alkamides; Reference Values; Sensitization; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Stimulation, Chemical; Time Factors; Tongue - drug effects; Vertebrates: nervous system and sense organs; Human; Sensitization; Desensitization; Piperine; Oral; Capsaicin; Tongue; Analgesic; Sensorial perception; Sensory receptor

Topical desensitization of the tongue was assessed during multiple bouts of exposure to capsaicin. In the first experiment subjects rated perceived irritation as 30 capsaicin stimuli (33 μM) were applied to the tongue tip in three blocks of 10, with 15 min breaks between blocks. Significant desensit...