Alterations in the pituitary-thyroid and pituitary-adrenal axes—consequences of long-term mifepristone treatment

• Published in: Metabolism, clinical and experimental Vol. 46; no. 3; pp. 292 - 296
• Main Authors: Heikinheimo, Oskari, Ranta, Sirpa, Grunberg, Steven, Lähteenmäki, Pekka, Spitz, Irving M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1997; Elsevier
• Subjects: Administration, Oral; Androstenedione - blood; Androstenedione - metabolism; Biological and medical sciences; Female; Hormone Antagonists - administration & dosage; Hormone Antagonists - chemistry; Hormone Antagonists - pharmacokinetics; Hormone Antagonists - pharmacology; Hormones. Endocrine system; Humans; Hydrocortisone - blood; Hydrocortisone - metabolism; Male; Medical sciences; Meningioma - blood; Meningioma - drug therapy; Meningioma - metabolism; Mifepristone - administration & dosage; Mifepristone - chemistry; Mifepristone - pharmacokinetics; Mifepristone - pharmacology; Pharmacology. Drug treatments; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - physiology; Prolactin - blood; Prolactin - drug effects; Prolactin - metabolism; Thyroid Gland - drug effects; Thyroid Gland - physiology; Thyrotropin - blood; Thyrotropin - drug effects; Thyrotropin - metabolism; Thyroxine - blood; Thyroxine - drug effects; Thyroxine - metabolism; Time Factors; Triiodothyronine - blood; Triiodothyronine - drug effects; Triiodothyronine - metabolism; Human; Correlation; Toxicity; Thyroid gland; Antihormone; Long term; Chemotherapy; Antiprogesterone; Hypophysoadrenal axis; Female; Thyroid hormone; Mifepristone; Hormonal investigation; Pharmacokinetics

The effects of short-term administration of the antiprogestin and antiglucocorticoid, mifepristone, have been well characterized. However, little is known about the effects of prolonged administration of mifepristone. We analyzed hormonal parameters in four female and three male patients with unrese...